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Effect of the Ac-D-MPRG Peptide Based on the C-Terminal Fragment of Arginine-Vasopressin(6–9) on the Behavior of Rats of Different Ages

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Abstract

It was found that Ac-D-MPRG, a tetrapeptide synthesized on the basis of the C-terminal fragment of arginine-vasopressin(6–9), affects anxiety and orienting-exploratory behavior in rats of all three studied age groups upon chronic neonatal administration. It was also found that the peptide has the most pronounced effect under stress conditions. A reduced level of anxiety, which manifested in a decrease in the number of grooming acts in the Elevated Plus Maze test and an increase in the time spent in the light compartment in the Light-Dark Chamber test, was observed in rats treated with the peptide at all three studied doses. Motor activity changed from passive hiding in the prepubertal period to active avoidance in the pubertal period and in adult animals. Based on the obtained data, it can be concluded that the peptide exhibits its effect only in the presence of biologically significant stimuli.

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Funding

The work was supported by the state task of Moscow State University (no. 121032300071-8) without the support of public or private funds under the agreement on scientific and technical cooperation between the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus and the Biology Faculty.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Faculty of Biology, Moscow State University, 119234, Moscow, Russia

    A. A. Stakhanova, O. G. Voskresenskaya & A. A. Kamensky

  2. Applied Biochemistry Laboratory, Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    V. P. Golubovich

Authors
  1. A. A. Stakhanova
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  2. O. G. Voskresenskaya
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  3. V. P. Golubovich
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  4. A. A. Kamensky
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Corresponding author

Correspondence to A. A. Stakhanova.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

STATEMENT ON THE WELFARE OF ANIMALS

The experiments were carried out in compliance with the ethical standards of working with animals and were approved by the commission of Moscow State University on bioethics (protocol no. 107-d).

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Translated by M. Shulskaya

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Stakhanova, A.A., Voskresenskaya, O.G., Golubovich, V.P. et al. Effect of the Ac-D-MPRG Peptide Based on the C-Terminal Fragment of Arginine-Vasopressin(6–9) on the Behavior of Rats of Different Ages. Moscow Univ. Biol.Sci. Bull. 78, 100–105 (2023). https://doi.org/10.3103/S0096392523020098

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  • DOI: https://doi.org/10.3103/S0096392523020098

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