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Effect of carnosine on conditioned passive avoidance response in the norm and under hypoxia conditions

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Abstract

We studied the effect of the histidine-containing dipeptide carnosine in the norm and under hypoxia conditions on the conditioned passive avoidance response in a three-compartment chamber, which consisted of a light compartment, a dark dangerous compartment where the rat received a foot shock, and a dark safety compartment, where the rat did not receive a foot shock. We found that carnosine normalized physiological indices, which were impaired by acute exposure to hypobaric hypoxia, and increased the number of choices of the safety compartment in both intact rats and rats subjected to hypoxia.

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Authors and Affiliations

  1. Department of Biology, Moscow State University, Moscow, 119992, Russia

    D. S. Berezhnoy & A. N. Inozemtsev

  2. North-Ossetian State University, Vladikavkaz, 362025, Russia

    S. B. Bokieva

  3. Scientific Center for Neurology, Moscow, 125367, Russia

    S. L. Stvolinskii & T. N. Fedorova

Authors
  1. D. S. Berezhnoy
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  2. S. B. Bokieva
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  3. S. L. Stvolinskii
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  4. T. N. Fedorova
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  5. A. N. Inozemtsev
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Correspondence to D. S. Berezhnoy.

Additional information

Original Russian Text © D.S. Berezhnoy, S.B. Bokieva, S.L. Stvolinskii, T.N. Fedorova, A.N. Inozemtsev, 2015, published in Vestnik Moskovskogo Universiteta. Biologiya, 2015, No. 3, pp. 3–7.

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Berezhnoy, D.S., Bokieva, S.B., Stvolinskii, S.L. et al. Effect of carnosine on conditioned passive avoidance response in the norm and under hypoxia conditions. Moscow Univ. Biol.Sci. Bull. 70, 105–109 (2015). https://doi.org/10.3103/S0096392515030037

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