Abstract
Effects of the selective D2 receptors antagonist clebopride on behavior of adult male rats was studied in such tests as sucrose consumption, open field, elevated plus maze, and complex maze with food reinforcement. The drug was injected in small doses (0.2 and 0.4 mg/kg) chronically within two weeks. It was shown that clebopride may have an influence on emotional and motivational state of experimental animals, on the one hand, causing depressive-like changes, and on the other hand, improving learning ability and exploratory reactions. A variety of consequences of D2 antagonist action is caused, apparently, by a competition of its post- and presynaptic effects.
Similar content being viewed by others
References
Byrnes, E.M., Ughrin, Y., and Bruno, J.P., Developmental plasticity in the D1- and D2-mediation of motor behavior in rats depleted of dopamine as neonates, Dev. Psychobiol., 1996, vol. 29, no. 8, pp. 653–666.
D’Haen, H. and Bossuty, A., Dopamine D2 receptors in depression measured with single photon emission computed tomography, Biol. Psych., 1994, vol. 35, no. 2, pp. 128–132.
Drago, F., Arezzi, A., and Vitzl, A., Effects of acute of chronic administration of substituted benzamides in experimental models of depression in rats, Eur. Neuropshychopharmacol., 2000, vol. 10, no. 6, pp. 437–442.
D’Aquila, P.S., Collu, M., Gessa, G.L., and Serra, G., The role dopamine in the mechanism of action of antidepressant drugs, Eur. J. Pharmacol., 2000, vol. 405, nos. 1–3, pp. 365–373.
Sarkisova, K. and van Luijtelaar, G., The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression, Proc. Neuropsychopharmacol. Biol. Psych., 2011, vol. 35, no. 4, pp. 854–876.
Dobryakova, Yu.V., Dubynin, V.A., and Van Luiitelaar, Zh., Maternal behavior of WAG/Rij rats in health and under the action on the dopaminergic system of the brain, Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova, 2010, vol. 60, no. 3, pp. 372–380.
Sarkisova, K.Yu., Kulikov, M.A., and Shatskova, A.B., Are WAG/Rij rats with genetic absence epilepsy anxious? Vyssh. Nervn. Deyat. im. I. P. Pavlova, 2005, vol. 5, no. 2, pp. 241–249.
Dubynin, V.A. and Kamenskii, A.A., Beta-kazomorfiny i ikh rol’ v regulyatsii povedeniya (Beta-Casomorphins and Their Role in the Regulation of Behavior), Moscow: KMK, 2010.
Belyaeva, Yu.A., Dubynin, V.A., Stovolosov, I.S., Dobryakova, Yu.V., Bespalova, Zh.D., and Kamenskii, A.A., Effects of acute and chronic administration of exorphin C on behavior and learning in white rat pups, Moscow Univ. Biol. Sci. Bull., 2009, vol. 64, no. 2, pp. 13–18.
Benoit-Marand, M., Borrelli, E., and Conon, F., Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo, J. Neurosci., 2001, vol. 21, no. 23, pp. 9134–9141.
Wasti, A. and Siddiqui, N.A., Alterations in the level of neurotransmitters associated with the chronic treatment of antipsychotic drugs, J. Pak. Med. Assoc., 2010, vol. 60, no. 8, pp. 628–632.
Lee, J., Parish, C.L., Tomas, D., and Horne, K., Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behavior, Neuroscience, 2011, vol. 174, pp. 143–150.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.V. Malyshev, A.M. Zakharov, K.Yu. Sarkisova, V.A. Dubynin, 2013, published in Vestnik Moskovskogo Universiteta. Biologiya, 2013, No. 4, pp. 3–8.
About this article
Cite this article
Malyshev, A.V., Zakharov, A.M., Sarkisova, K.Y. et al. Effects of chronic injections of clebopride in low doses on behavior reactions of white rats. Moscow Univ. Biol.Sci. Bull. 68, 153–157 (2013). https://doi.org/10.3103/S0096392514010076
Received:
Published:
Issue Date:
DOI: https://doi.org/10.3103/S0096392514010076