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Investigation of protective properties of Shigella sonnei carbohydrate biopolymers under experimental endotoxic shock models

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Abstract

We studied tolerogenic properties of new nonpyrogenic low-endotoxic complex preparation composed of Shigella sonnei carbohydrate biopolymers under D-galactosamine and direct experimental endotoxic shock models. Pretreatment with complex preparation (exopolysaccharide + lipopolysaccharide) S. sonnei protects mice (CBA × C57B1/6)F1 against lipopolysaccharide (E. coli O:55)-mediated death. We demonstrate correlation between increasing preimmunization dose of complex preparation with rate of survival and reduction of TNF-α serum level under a direct endotoxic shock model.

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References

  1. Cross, A.S., Opal, S.M., Warren, H.S., Palardy, J.E., Glaser, K., Parejo, A., and Bhattacharjee, A.K., Active Immunization with a Detoxified Escherichia coli J5 Lipopolysaccharide Group B Meningococcal Outer Membrane Protein Complex Vaccine Protects Animals from Experimental Sepsis, J. Infect. Dis., 2001, no. 183, pp. 1079–1086.

    Google Scholar 

  2. Astiz, M.E. and Rackow, E.C., Septic Shock, Lancet, 1998, no. 361, pp. 1501–1505.

    Google Scholar 

  3. Dinarello, C., Cytokines As Mediators in the Pathogenesis of Septic Shock, Curr. Topics Microbiol. Immunol., 1996, no. 216, pp. 133–165.

    Google Scholar 

  4. Ulloa, L. and Tracey, K.J., The “Cytokine Profile”: A Code for Sepsis, Trends Mol. Med., 2005, no. 11, pp. 56–63.

    Google Scholar 

  5. Madonna, G.S., Peterson, J.E., Ribi, E.E., and Vogel, S.N., Early-Phase Endotoxin Tolerance: Induction by Detoxified Lipid A Derivative, Monophosphoryl Lipid A, Infect. Immun., 1986, vol. 1, no. 52, pp. 6–11.

    Google Scholar 

  6. Dinarello, C.A., Immediate Cytokine Responses to Endotoxin: Tumor Necrosis Factor α and Interleukin-1 Family, in Endotoxin in Health and Disease, Brade, H., Ed., New York: Marcell Dekker, 1999, pp. 817–830.

    Google Scholar 

  7. van Emersfoort, E.S., van Berkel, T.J., and Kuiper, J., Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock, Clin. Microbial. Rev., 2003, vol. 3, no. 16, pp. 379–414.

    Article  Google Scholar 

  8. Lehmann, B.V., Freudenberg, M.A., and Galanos, G., Lethal Toxicity of Lipopolysaccharide and Tumor Necrosis Factor in Normal and D-Galactosamine-Treated Mice, J. Exp. Med., 1987, no. 165, pp. 657–663.

    Google Scholar 

  9. Tiegs, G., Wolter, M., and Wendel, A., Tumour Necrosis Factor Is a Terminal Mediator in Galactosamine/Endotoxin-Induced Hepatitis in Mice, Biochem. Pharmacol., 1989, no. 38, pp. 627–631.

    Google Scholar 

  10. Mignon, A., Rouquet, N., Fabre, M., Martin, S., Pages, J.C., Dhainaut, J.F., Kahn, A., Briand, P., and Joulin, V., LPS Challenge in D-Galactosamine-Sensitized Mice Accounts for Caspase-Dependent Fulminant Hepatitis, Not for Septic Shock, Am. J. Respir. Crit. Care Med., 1999, no. 159, pp. 1308–1315.

    Google Scholar 

  11. Johnston, C.A. and Greisman, S.E., Mechanism of Endotoxin Tolerance, in Handbook of Endotoxin, vol. 2: Pathophysiology of Endotoxin, Hishaw, L.B., Ed., New York: Elsevier, 1985, pp. 359–391.

    Google Scholar 

  12. Suffredini, A.F., Reda, D., Banks, S.M., Tropea, M., Agosti, J.M., and Miller, R., Effects of Recombinant Dimeric TNF-α Receptor on Human Inflammatory Responses Following Intravenous Endotoxin Administration, J. Immunol., 1995, no. 155, pp. 5038–5045.

    Google Scholar 

  13. Marano, M.A., Fong, Y., Moldawer, L.L., Wei, H., Calvano, S.E., Tracey, K.J., Barie, J.S., Manogue, K., Cerami, A., Shires, G.T.G., and Lowry, S.F., Serum Cachectin/Tumor Necrosis Factor in Critically Ill Patients with Burns Correlate with Infection and Mortality, Surg. Gynecol. Obstet., 1990, no. 170, pp. 32–38.

    Google Scholar 

  14. Christman, J.W., Lancaster, L.H., and Blackwell, T.S., Nuclear Factor B: A Pivotal Role in the Systemic Inflammatory Response Syndrome and New Target for Therapy, Intens. Care Med., 1998, no. 24, pp. 1131–1138.

    Google Scholar 

  15. Schade, F., Flach, R., Flohe, S., Majetschak, M., Kreuzfelder, E., Dominguez-Fernandes, E., Borgermann, J., Reuter, M., and Obertacke, U., Endotoxin Tolerance, in Endotoxin in Health and Disease, Brade, H., Ed., New York: Marcell Dekker, 1999, pp. 751–767.

    Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Moscow State University, Moscow, Russia

    A. A. Markina & I. A. Kondratieva

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  1. A. A. Markina
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  2. I. A. Kondratieva
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Correspondence to A. A. Markina.

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Original Russian Text © A.A. Markina, I.A. Kondratieva, 2013, published in Vestnik Moskovskogo Universiteta. Biologiya, 2013, No. 3, pp. 12–15.

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Markina, A.A., Kondratieva, I.A. Investigation of protective properties of Shigella sonnei carbohydrate biopolymers under experimental endotoxic shock models. Moscow Univ. Biol.Sci. Bull. 68, 100–103 (2013). https://doi.org/10.3103/S0096392513020053

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  • DOI: https://doi.org/10.3103/S0096392513020053

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