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Modulation of nitric oxide (NO) biosynthesis in lactobacilli

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Abstract

We characterized effects of nitric oxide synthase (NOS) substrate L-arginine and classical inhibitors of mammalian NOS on nitric oxide (NO) biosynthesis in probiotic bacteria Lactobacillus plantarum 8P-A3. NO-synthase origin of nitric oxide detected by fluorescent NO indicator 1,2-diaminoanthraquinone (DAA) was confirmed by induction of NO production by exogenous L-arginine. None of the used inhibitors of three isoforms of mammalian NOSs (L-NAME, L-NIL, nNOS inhibitor I) showed significant inhibitory effect of lactobacillar NO-synthase activity.

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References

  1. Adawi, D., Kasravi, F.B., Molin, G., and Jeppsson, B., Effect of Lactobacillus Supplementation with and with-out Arginine on Liver Damage, Bacterial Translocation in an Acute Liver Injury Model in the Rat, Hepatology, 1997, vol. 25, no. 3, pp. 642–647.

    Article  PubMed  CAS  Google Scholar 

  2. Alderton, W.K., Cooper, C.E., and Knowles, R.G., Nitric Oxide Synthases: Structure, Function and Inhibition, Biochem. J., 2001, vol. 357, pp. 593–615.

    Article  PubMed  CAS  Google Scholar 

  3. Choi, W.S., Seo, D.W., Chang, M.S., Han, J.W., Hong, S.Y., Paik, W.K., and Lee, H.W., Methylesters of L-Arginine and N-Nitro-L-arginine Induced Nitric Oxide Synthase in Staphylococcus aureus, Biochem. Biophys. Res. Commun., 1998, vol. 246, pp. 431–435.

    Article  PubMed  CAS  Google Scholar 

  4. Tsikas, D., Boger, R.H., Sandmann, J., Bode-Boger, S.M., and Frolich, J.C., Endogenous Nitric Oxide Synthase Inhibitors Are Responsible for the L-Arginine Paradox, FEBS Lett., 2000, vol. 478, pp. 1–3.

    Article  PubMed  CAS  Google Scholar 

  5. Wach, M.J., Kers, J.A., Krasnoff, S.B., Loria, R., and Gibson, D.M., Nitric Oxide Synthase Inhibitors and Nitric Oxide Donors Modulate the Biosynthesis of Thaxtomin A, a Nitrated Phytotoxin Produced by Streptomyces spp., Nitric Oxide, 2005, vol. 12, pp. 46–53.

    Article  PubMed  CAS  Google Scholar 

  6. Yarullina, D.R., Il’inskaya, O.N., Aganov, A.V., Silkin, N.I., and Zverev, D.G., Alternative Pathways of Nitric Oxide Formation in Lactobacilli: Evidence for Nitric Oxide Synthase Activity by EPR, Mikrobiologiya, 2006, vol. 75, no. 6, pp. 731–736 [Microbiology (Engl. Transl.), 2006, vol. 75, no. 6, pp. 634–638].

    Google Scholar 

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Authors and Affiliations

  1. Kazan (Volga Region) Federal University, Kazan, Russia

    D. R. Yarullina, O. A. Smolentseva & O. N. Ilinskaya

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  1. D. R. Yarullina
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  2. O. A. Smolentseva
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  3. O. N. Ilinskaya
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Correspondence to D. R. Yarullina.

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Original Russian Text © D.R. Yarullina, O.A. Smolentseva, O.N. Ilinskaya, 2011, published in Vestnik Moskovskogo Universiteta. Biologiya, 2011, No. 2, pp. 41–43.

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Yarullina, D.R., Smolentseva, O.A. & Ilinskaya, O.N. Modulation of nitric oxide (NO) biosynthesis in lactobacilli. Moscow Univ. Biol.Sci. Bull. 66, 79–80 (2011). https://doi.org/10.3103/S0096392511020155

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  • DOI: https://doi.org/10.3103/S0096392511020155

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