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An estimate of polymorphism of ADH1B, ALDH2, and CYP2E1 alcohol biotransformation genes in Siberian indigenous and immigrant populations

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Abstract

In the present article, the polymorphism of ADH1B, ALDH2, and CYP2E1 genes is studied in populations of Shors, Russians of Siberia, and progenies of mixed Russian-Shor marriages. Reliable differences between groups according to the frequency of ADH1B, ALDH2, and CYP2E1 genotypes and alleles are revealed. The article shows the high heterozygosis levels of the ADH1B and ALDH2 genes. Gene distances prove that mongrels and Shors are very close to each other (d = 0.005) and Russians of Siberia are not similar to the Russians of the Central Russia (d = 0.046).

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Authors and Affiliations

  1. Faculty of Genetics, Kemerovo State University, Kemerovo, Russia

    N. V. Solopekin

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  1. N. V. Solopekin
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Correspondence to N. V. Solopekin.

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Original Russian Text © N.V. Solopekin, 2011, published in Vestnik Moskovskogo Universiteta. Biologiya, 2011, No. 2, pp. 32–34.

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Solopekin, N.V. An estimate of polymorphism of ADH1B, ALDH2, and CYP2E1 alcohol biotransformation genes in Siberian indigenous and immigrant populations. Moscow Univ. Biol.Sci. Bull. 66, 71–72 (2011). https://doi.org/10.3103/S0096392511020088

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  • DOI: https://doi.org/10.3103/S0096392511020088

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