Skip to main content

Advertisement

Log in

Mobile element Gypsy (Mdg4)—Endoparasyte of Drosophila melanogaster: Regulation of transposition and infection characteristics

  • Published:
Moscow University Biological Sciences Bulletin Aims and scope Submit manuscript

Abstract

By the example of MDG4 (gypsy) of Drosophila melanogaster, characteristics of endogenous invertebrate retroviruses of the errantiviruses class (Errantiviridae, Metaviridae) are analyzed. Ways of the evolution of retroviruses of invertebrates together with possible mechanisms of their origin from retrotransposons via the addition of viral genes from other systematic groups are discussed. It has been demonstrated that the locus flamenco plays an important role in providing the internal immunity against MDG4 (gypsy) in Drosophila melanogaster.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  • Arkhipova, I.R., Lyubomirskaya, N.V., and Ilyin, Yu.V., Molecular Biology Intelligence Unit: Drosophila Retrotransposons, Texas R.G., Austin, 1995.

    Google Scholar 

  • Boeke, J.D., Eickbush, T.H., Sandmeyer, S.B., and Voytas, D.F., Virus Taxonomy: ICTV VIIth Report, Murphy, F.A., Ed., New York, 2006 (http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs-index.htm).

  • Brasset, E.E., Taddei, A.R., Arnaud, F.F., Faye, B.B., Fausto, A.V., Mazzini, M.M., Giorgi, F.F., and Vaury, C.C., Viral Particles of the Endogenous Retrovirus ZAM from Drosophila melanogaster Use a Pre-Existing Endosome/Exosome Pathway for Transfer to the Oocyte, Retrovirology, 2006, vol. 3, no. 1, p. 25.

    Article  PubMed  CAS  Google Scholar 

  • Chalvet, F., Debec, A., Marcaillou, C., Rougeau, C., and Bucheton, A., Morphological and Molecular Characterization of New Drosophila Calls Lines Established from a Strain Permissive for Gypsy Transposition, In Vitro Cell Dev. Biol. Anim., 1998, vol. 34, pp. 799–804.

    Article  PubMed  CAS  Google Scholar 

  • Clark, J.B., Maddison, W.P., and Kidwell, M.G., Phylogenetic Analysis Supports Horizontal Transfer of P Transposable Elements, Mol. Biol. Evol., 1994, vol. 11, no. 1, pp. 40–50.

    PubMed  CAS  Google Scholar 

  • Coffin, J.M., Hughes, S.H., and Varmus, H.E., Retroviruses, New York: Cold Spring Harbor Laboratory Press, 1999.

    Google Scholar 

  • Glukhov, I.L., Il’in, Yu.V., and Ivanov, V.A., Specific Endonuclease Activity of Integrase Encoded by the mdg4 (gypsy) Retrotransposon, Mol. Biol., 2000, vol. 34, no. 2, pp. 277–284.

    Article  CAS  Google Scholar 

  • Hoffman, J.A. and Reichhart, J.M., Drosophila Innate Immunity: An Evolutionary Perspective, Nature Immunol., 2002, vol. 3, no. 2, pp. 121–126.

    Article  Google Scholar 

  • Ilyin, Y.V., Lyubomirskaya, N.V., and Kim, A.I., Retrotransposon gypsy and Genetic Instability in Drosophila, Genetica (Netherlands), 1991, vol. 85, no. 1, pp. 13–22.

    CAS  Google Scholar 

  • Jordan, I.K., Matyunina, L.V., and McDonald, J.F., Evidence for the Recent Horizontal Transfer of Long Terminal Repeat Transposon, Proc. Natl. Acad. Sci. USA, 1999, vol. 96, pp. 12 621–12 625.

    Article  CAS  Google Scholar 

  • Kim, A.I. and Belyaeva, E.S., Transpozitsii MDG4 na fone neizmennoi lokalizatsii drugikh mobil’nykh elementov v mutatornoi linii Drosorhila melanogaster, kharakterizuy-ushcheisya geneticheskoi nestabil’nost’yu, Dokl. Akad. Nauk SSSR, 1986, vol. 289, no. 5, pp. 1248–1252.

    CAS  Google Scholar 

  • Kim, A.I., Belyaeva, E.S., and Aslanian, M.M., Autonomous Transposition of gypsy Mobile Elements and Genetic Instability in Drosophila melanogaster, Mol. Gen. Genet., 1990, vol. 224, vol. no. 2, pp. 303–308.

    Article  PubMed  CAS  Google Scholar 

  • Kim, A.I., Belyaeva, E.S., Larkina, Z.G., and Aslanyan, M.M., Genetic Instability and Transposition of Mobile Element mdg4 in a Mutator Strain of Drosophila melanogaster, Genetika, 1989, vol. 25, no. 10, pp. 1747–1756.

    PubMed  CAS  Google Scholar 

  • Kim, A.I., Lyubomirskaya, N.V., Belyaeva, E.S., Shostak, N.G., and Ilyin, Y.V., The Introduction of Transpositionally Active Copy of a Retrotransposon gypsy into the Stable Strain of Drosophila melanogaster, Mol. Gen. Genet., 1994, vol. 242, no. 4, pp. 472–477.

    Article  PubMed  CAS  Google Scholar 

  • Kim, A.I., Pasyukova, E.G., Karpova, N.N., and Razorenova, O.V., Genome Factors Controlling Transposition of Mobile Elements in Drosophila, Genetika, 1999, no. 11, pp. 1511–1521.

  • Kim, A.I., Terzian, C., Santamaria, P., Pelisson, A., Prud’homme, N., and Bucheton, A., Retrovirures in Invertebrates: the gypsy Retrotransposon Is Apparently an Infectious Retrovirus of Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 1994, vol. 91, no. 4, pp. 1285–1289.

    Article  PubMed  CAS  Google Scholar 

  • Koonin, E.V., Mushegian, A.R., Ryabov, E.V., and Dolja, V.V., Diverse Groups of Plant RNA and DNA Viruses Share Related Movements Proteins That May Possess Chaperone-Like Activity, J. Gen. Virol., 1991, vol. 72, pp. 2895–2903.

    Article  PubMed  Google Scholar 

  • Kousoulidou, L.K., Karpova, N.N., Razorenova, O.V., Glukhov, I.A., Kim, A.I., Lyubomirskaya, N.V., and Il’in, Yu.V., Mobile Genetic Element gypsy (MDG4) in Drosophila melanogaster Strains: Structural Characteristics and Regulation of Transposition, Genetika, 2001, vol. 37, no. 12, pp. 1587–1597.

    Google Scholar 

  • Kuzin, A.B., Lyubomirskaya, N.V., Il’in, Yu.V., Khudaibergenova, B.M., and Kim, A.I., Hot Point of the MDG4 Retrotransposon Insertion into the Locus forked and its Precise Excision, Dokl. Akad. Nauk, 1994a, vol. 335, no. 56, pp. 656–658.

    PubMed  CAS  Google Scholar 

  • Kuzin, A.B., Lyubomirskaya, N.V., Khudaibergenova, B.M., Ilyin, Y.V., and Kim, A.I., Precise Excision of the Retrotransposon gypsy from the Forked and Cut Loci in a Genetically Unstable D. melanogaster Strain, Nucleic Acid Res., 1994b, vol. 22, no. 22, pp. 4641–6445.

    Article  PubMed  CAS  Google Scholar 

  • Lecher, P., Bucheton, A., and Pelisson, A., Expression of the Drosophila Retrovirus gypsy As Ultrastructually Detectable Particles in the Ovaries of Flies Carrying a Permissive Flamenco Allele, J. Gen Virol., 1997, vol. 78, no. 9, pp. 2379–2378.

    PubMed  CAS  Google Scholar 

  • Lim, J.K., Simmons, M.J., Raymond, J.D., Cox, N.M., Doll, R.F., and Culbert, T.P., Homologue Destabilization by a Putative Transposable Element in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 1983, vol. 80, no. 21, pp. 6624–6627.

    Article  PubMed  CAS  Google Scholar 

  • Lyubomirskaya, N.V., Arkhipova, I.R., Il’in, Yu.V., and Kim, A.I., Cloning and Molecular Analysis of Retrotransposon mdg4 from two Drosophila melanogaster Strains, Differing in Genetic Instability, Genetika, 1990, vol. 26, no. 12, pp. 2101–2110.

    CAS  Google Scholar 

  • Lyubomirskaya, N.V., Shostak, N.G., Kuzin, A.B., Khudaibergenova, B.M., Il’in, Yu.V., and Kim, A.I., Introduction of a Single Transpositionally-Active Copy of MDG4 into the Genome of a Stable Line of Drosophila melanogaster Causes Genetic Instability, Genetika, 1994, vol. 30, no. 6, pp. 743–748.

    CAS  Google Scholar 

  • Lyubomirskaya, N.V., Smirnova, Y.B., Razorenova, O.V., Karpova, N.N., Surkov, S.A., Avedisov, S.N., Kim, A.I., Retrotransposon gypsy (Mdg4): Structural and Functional Differences, Distribution in Fly Stocks, Mol. Gen. Genet., 2001, vol. 265, no. 2, pp. 367–374.

    CAS  Google Scholar 

  • Malik, H.S., Henikoff, S., and Eickbush, T., Poised for Contagion: Evolutionary Origins of the Infection Abilities of Invertebrate Retroviruses, Genome Res., 2000, vol. 10, no. 9, pp. 1307–1318.

    Article  PubMed  CAS  Google Scholar 

  • McClintock, B., Chromosome Organization and Genetic Expression, in Cold Spring Harbor Symposia on Quantitative Biology, 1951, pp. 13–47.

  • Mejlumian, L., Pelisson, A., Bucheton, A., and Terzian, C., Comparative and Functional Studies of Drosophila Species Invasion by the gypsy Endogenous Retrovirus, Genetics, 2002, vol. 160, no. 1, pp. 201–209.

    PubMed  CAS  Google Scholar 

  • Nefedova, L.N., Lyubomirskaya, N.V., Il’in, Yu.V., and Kim, A.I., Precise Excision of Long Terminal Repeats of the mdg4 (gypsy) Retrotransposon of Drosophila melanogaster Detected in Escherichia coli Cells Is Explained by Its Integrase Function, Genetika, 2006, vol. 42, no. 12, pp. 1654–1661.

    Google Scholar 

  • Pelisson, A., Song, S.U., Prud’homme, N., Smith, P.A., Bucheton, A., and Corces, V.G., Gypsy Transposition Correlates with the Production of a Retroviral Envelope-Like Protein under the Tissue-Specific Control of the Drosophila Flamenco Gene, EMBO J., 1994, vol. 13, pp. 4401–4411.

    PubMed  CAS  Google Scholar 

  • Pelisson, A., Teysset, L., Chalvet, F., Kim, A., Prudhomme, N., Terzian, C., and Bucheton, A., About the Origin of Retroviruses and Co-Evolution of the gypsy Retrovirus with the Drosophila flamenco Host Gene, Genetica (Netherlands), 1997, vol. 100, no. 1, pp. 29–37.

    CAS  Google Scholar 

  • Prud’homme, N., Gans, M., Masson, M., Terzian, C., and Bucheton, A., Flamenco, a Gene Controlling the gypsy Retrovirus of Drosophila melanogaster, Genetics, 1995, vol. 139, no. 2, pp. 697–711.

    PubMed  Google Scholar 

  • Razorenova, O.V., Karpova, N.N., Smirnova, Yu.B., Kousoulidou, L.K., Reneva, N.K., Subocheva, E.A., Kim, A.I., Lyubomirskaya, N.V., and Il’in, Yu.V., The Distribution in Different Strains and Characteristic Features of Two Subfamilies of Drosophila melanogaster Retrotransposon MDG4 (gypsy), Genetika, 2001, vol. 37, no. 2, pp. 175–182.

    PubMed  CAS  Google Scholar 

  • Roberson, H.M., Multiple mariner Transposons in Flatworms and Hydras Are Related to Those of Insects, J. Hered., 1997, vol. 88, pp. 195–201.

    Google Scholar 

  • Robert, V., Prudhomme, N., Kim, A., Bucheton, A., and Pelisson, A., Characterization of the Flamenco Region of the Drosophila melanogaster Genome, Genetics, 2001, vol. 158, pp. 701–713.

    PubMed  CAS  Google Scholar 

  • Song, S.U., Gerasimova, T., Kurkulos, M., Boeke, J.D., and Corces, V.G., An Env-Like Protein Encoded by a Drosophila Retroelement: Evidence That gypsy Is an Infectious Retrovirus, Genes Dev., 1994, vol. 8, pp. 2046–2057.

    Article  PubMed  CAS  Google Scholar 

  • Song, S.U., Kurkulos, M., Boeke, J.D., and Corces, V.G., Infection of the Germ Line by Retroviral Particles Produced in the Follicle Cells: a Possible Mechanism for the Mobilization of the gypsy Retroelements of Drosophila, Development, 1997, vol. 124, no. 14, pp. 2789–2798.

    PubMed  CAS  Google Scholar 

  • Terzian, C., Ferraz, C., Demaille, J., and Bucheton, A., Evolution of the gypsy Endogenous Retrovirus in the Drosophila melanogaster Subgroup, Mol. Biol. Evol., 2000, vol. 17, no. 6, pp. 908–914.

    PubMed  CAS  Google Scholar 

  • Wasserman, S.A., Nature’s Fortress against Infection, Nature Immunol., 2004, vol. 5, no. 5, pp. 474–475.

    Article  CAS  Google Scholar 

  • Xiong, Y. and Eickbush, T.H., Origin and Evolution of Retroelements Based on Their Reverse Transcriptase Sequences, EMBO J., 1990, vol. 9, pp. 3353–3362.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. I. Kim.

Additional information

Original Russian Text © A.I. Kim, 2006, published in Vestnik Moskovskogo Universiteta. Biologiya, 2009, No. 2, pp. 26–32.

About this article

Cite this article

Kim, A.I. Mobile element Gypsy (Mdg4)—Endoparasyte of Drosophila melanogaster: Regulation of transposition and infection characteristics. Moscow Univ. Biol.Sci. Bull. 64, 78–83 (2009). https://doi.org/10.3103/S0096392509020059

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S0096392509020059

Key words