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Impact of Different DNA Ploidy Patterns on Endometrial Carcinomas Based on Image Cytometry

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Abstract

Worldwide, endometrial cancer is one of the most frequently diagnosed malignancies in women and a notable cause of death. The aim of this study was to perform image cytometric DNA ploidy analysis on a prospective material of endometrial adenocarcinomas in order to determine potential correlation between ploidy status and their histological features. The analysis was carried out in fresh tissue samples resected by implementing complete hysterectomy in a series of patients (n = 126). We found that ploidy status using image cytometry correlate with histologic type, grade and stage in endometrial cancer and aneuploid tumor samples are associated with aggressive phenotype statistics. Furthermore, DNA ploidy should be used as a reliable and applicable prognostic marker in the routine clinical practice.

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ACKNOWLEDGMENTS

The authors would like to thank Dr Karakitsos Petros (Professor, MD, PhD, ex Director, Department of Cytopathology, University General Hospital “Attikon”, School of Medicine, National and Kapodistrian University of Athens) for his contribution in evaluating the results.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

Author information

Authors and Affiliations

  1. Department of Cytopathology, 417 Army Equity Fund Hospital (NIMTS), 11521, Athens, Greece

    Kosmas Konstantinos, Riga Nefeli Georgia & Tsiambas Evangelos

  2. Department of Histopathology, “Ippokratio” General Hospital of Athens, 11527, Athens, Greece

    Riga Dimitra

  3. Department of Gynaecology, 417 Army Equity Fund Hospital (NIMTS), 11521, Athens, Greece

    Karachaliou Christina

  4. Department of Pathology, 417 Army Equity Fund Hospital (NIMTS), 11521, Athens, Greece

    Papazian Maria

  5. Department of Histopathology, “Andreas Sygros” Hospital of Athens, 16121, Athens, Greece

    Sofopoulos Michail

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  1. Kosmas Konstantinos
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  2. Riga Dimitra
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  3. Karachaliou Christina
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  4. Papazian Maria
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  6. Riga Nefeli Georgia
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Contributions

Conceptualization, methodology, investigation, writing original draft, writing review and editing: Kosmas Konstantinos, Riga Dimitra. Investigation, data curation: Karachaliou Christina, Papazian Maria. Investigation, validation: Riga Nefeli Georgia. Supervision, validation: Sofopoulos Michail. Supervision, validation, writing review and editing: Tsiambas Evangelos.

Corresponding author

Correspondence to Kosmas Konstantinos.

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All authors agreed with the final version of the manuscript and the order of authors.

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The authors of this work declare that they have no conflict of interest.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The research was approved by the Ethics Review Committee of 417 Army Equity Fund Hospital of Athens, Greece (Approval number and date: 1/100/16.01.24).

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Konstantinos, K., Dimitra, R., Christina, K. et al. Impact of Different DNA Ploidy Patterns on Endometrial Carcinomas Based on Image Cytometry. Cytol. Genet. 58, 53–59 (2024). https://doi.org/10.3103/S0095452724010092

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