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RETRACTED ARTICLE: Sodium ferulate inhibits high-fat diet-induced inflammatory factors expression in human umbilical vein endothelial cells

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Abstract

Vascular inflammation is an important hallmark of atherosclerosis caused by high-fat diet. Oxidized low-density lipoprotein (ox-LDL) is a key initiator of inflammation as it activates vascular endothelial cells to induce the expression of inflammatory genes. Sodium ferulate (SF), an active component from Chinese medicine, was reported to have potential of anti-atherosclerotic activity. However, little is known about the mechanism. In present research we investigated how SF changed the cellular gene expression profile and restored ox-LDL-triggered inflammation in HUVECs. Cellular gene expression profile, the production of inflammatory genes and NF-κВ activation were investigated in human umbilical vein endothelial cells with or without SF (5 μM) treatment after precondition with ox-LDL (50 μg/mL). Ox-LDL treatment increased the production of inflammatory factors, including IL-1β, CCL20, IL-6, IL-8 and CXCL1. SF stimulation modulated the translocation of NF-κВ between cytoplasm and nucleus, and alleviated the inflammatory response induced by ox-LDL. Collectively, SF appeared to be able to suppress the expression of inflammatory factors in ox-LDL-stimulated endothelial cells, and transcription factor NF-κB might be involved in such process.

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Authors and Affiliations

  1. School of Public Health, Wuhan University, Wuhan, 430072, China

    Junliang Tao, Yonghong Man, Weina Wang & Yongyi Bi

  2. Nanyang Medical College, Nanyang, 473000, China

    Junliang Tao, Dongxian Zhang, Yonghong Man & Weina Wang

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  1. Junliang Tao
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  2. Dongxian Zhang
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  4. Weina Wang
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Correspondence to Yongyi Bi.

Additional information

The article is published in the original.

This article has been retracted by the Editor-in-Chief as it duplicates the earlier submission by the same authors published in Molecular and Cellular Toxicology, volume 12, no. 2, pp. 117–123, https://doi.org/10.1007/s13273-016-0015-0. The authors have not responded to the Editor-in-Chief’s letters regarding this retraction.

A correction to this article is available online at https://doi.org/10.3103/S0095452719010134.

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Tao, J., Zhang, D., Man, Y. et al. RETRACTED ARTICLE: Sodium ferulate inhibits high-fat diet-induced inflammatory factors expression in human umbilical vein endothelial cells. Cytol. Genet. 51, 214–220 (2017). https://doi.org/10.3103/S0095452717030124

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  • DOI: https://doi.org/10.3103/S0095452717030124

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