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Study of the canonical Wnt signaling activity in animals of different ages in the conditions of embryonic cardiac-specific β-catenin ablation

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Abstract

Using conditional-knockout animals, we studied the expression of the genes involved in the canonical Wnt signaling pathway (TCF-4, Axin-2) and the genes controlled by this signaling pathway (c-fos, cyclin D1, c-myc, and Cx43) in the myocardium of mice under the condition of embryonic cardio-specific ablation of one allele of the β-catenin gene. The inhibition of the canonical Wnt signaling was observed in all age groups tested (1, 3, and 6 months). An analysis of the genes controlled by the canonical Wnt pathway allowed us to reveal changes of their expression in the tissue of animals with cardiac-specific β-catenin haploinsufficiency. The importance of a normally functioning canonical Wnt signaling for the growth and development of the adult heart is especially underlined in the article.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, ul. Akademika Zabolotnogo 150, Kyiv, 03680, Ukraine

    O. L. Palchevska, L. L. Macewicz, O. O. Piven & L. L. Lukash

  2. Educational and Scientific Center Institute of Biology, Taras Shevchenko National University of Kyiv, pr. Akademika Glushkova 2, Kyiv, 03022, Ukraine

    O. L. Palchevska, V. V. Balatskii & A. O. Andrejeva

Authors
  1. O. L. Palchevska
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  2. V. V. Balatskii
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  3. A. O. Andrejeva
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  4. L. L. Macewicz
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  5. O. O. Piven
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  6. L. L. Lukash
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Correspondence to O. O. Piven.

Additional information

Original Ukrainian Text © O.L. Palchevska, V.V. Balatskii, A.O. Andrejeva, L.L. Macewicz, O.O. Piven, L.L. Lukash, 2015, published in Tsitologiya i Genetika, 2015, Vol. 49, No. 1, pp. 10–17.

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Palchevska, O.L., Balatskii, V.V., Andrejeva, A.O. et al. Study of the canonical Wnt signaling activity in animals of different ages in the conditions of embryonic cardiac-specific β-catenin ablation. Cytol. Genet. 49, 6–11 (2015). https://doi.org/10.3103/S0095452715010107

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  • DOI: https://doi.org/10.3103/S0095452715010107

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