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Effect of insulin-like growth factor transgene on wound healing in mice with streptozotocin-induced diabetes

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Abstract

Insulin-like growth factor 1 (IGF-1) is one of the main factors that can affect the condition and rate of skin regeneration process. Morphological and molecular biological investigations were carried out to study skin wounds of wild-type FVB mice and transgenic K14/mIGF-1 animals with streptozotocin-induced diabetes. Increases in the IGF-1 expression, the area and thickness of regenerated epithelium, and number of Mac-1+ cells per wound were shown in transgenic animals compared with wild-type animals.

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Authors and Affiliations

  1. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, ul. Vyshgorodskaya 67, Kyiv, 04114, Ukraine

    Yu. I. Leonov, M. S. Shkumat, P. P. Klymenko, M. Yu. Hovorun & I. M. Pishel

  2. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, ul. Leontovicha 9, Kyiv, 01030, Ukraine

    M. M. Guzyk & T. M. Kuchmerovska

Authors
  1. Yu. I. Leonov
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  2. M. S. Shkumat
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  3. P. P. Klymenko
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  4. M. Yu. Hovorun
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  5. M. M. Guzyk
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  6. T. M. Kuchmerovska
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  7. I. M. Pishel
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Correspondence to Yu. I. Leonov.

Additional information

Original Ukrainian Text © Yu.I. Leonov, M.S. Shkumat, P.P. Klymenko, M.Yu. Hovorun, M.M. Guzyk, T.M. Kuchmerovska, I.M. Pishel, 2015, published in Tsitologiya i Genetika, 2015, Vol. 49, No. 1, pp. 26–34.

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Leonov, Y.I., Shkumat, M.S., Klymenko, P.P. et al. Effect of insulin-like growth factor transgene on wound healing in mice with streptozotocin-induced diabetes. Cytol. Genet. 49, 19–26 (2015). https://doi.org/10.3103/S0095452715010065

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  • DOI: https://doi.org/10.3103/S0095452715010065

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