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Morphological and histochemical analysis of mucous membrane transformation of the artificial urinary bladder

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Abstract

The performed morphological study of the transformation mechanism of the intestinal reservoir of the mucous membrane using modern immunochemical and histochemical methods revealed three morphological phases of enteric epithelium adaptation: reactive-inflammatory, compensatory-protective, and atrophic. The enteric urinary reservoir preserves a cambial apparatus typical of the enteric phenotype with inherent apoptosis activity and proliferation, which confirms the low level of the tumor transformation risk.

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References

  1. Borden, L., Clark, P.E., Hall, M.C., Bladder Cancer, Curr. Opin. Oncol., 2005, vol. 17, pp. 275–280.

    Article  PubMed  Google Scholar 

  2. Madersbacher, S. and Studer, U.E., Contemporary Cystectomy and Urinary Diversion, World J. Urol., 2002, vol. 20, pp. 151–157.

    PubMed  Google Scholar 

  3. Orlandi, G., Guizzadi, S., Ferreti, S., Simonazzi, M., Bucci, G., and Gatti, R., Ultrastructural Basis for the Efficiency of an Ileal Orthotopic Neobladder 27 Years after Surgery, Urol. Int., 2004, vol. 69, pp. 233–235.

    Article  Google Scholar 

  4. Lin, D.W., Santucci, R.A., Mayo, M.E., et al., Urodynamic Evaluation and Long-term Results of the Orhotopic Gastric Neobladder in Men, J. Urol., 2000, vol. 164, pp. 356–359.

    Article  PubMed  CAS  Google Scholar 

  5. Gitlin, J.S., Xue-ru, Wu., Tung-tien, Sun., Ritchey, M.L., and Shapiro, E., New Concepts of Histological Changes in Experimental Augmentation Cytoplasty: Insights Into the Development of Neoplastic Transformation at the Enterovesical and Gastrovesical Anastomosis, J. Urol., 1999, vol. 162, pp. 1096–1100.

    Article  PubMed  CAS  Google Scholar 

  6. Gatti, R., Ferretti, S., Bucci, G., Simonazzi, M., Cortellini, P., and Orlandini, G., Histological Adaptation of Orthotopic Ileal Neobladder Mucosa: 4-Year Follow-Up of 30 Patients, Eur. Urol., 1999, vol. 36, no. 6, pp. 588–594.

    Article  PubMed  CAS  Google Scholar 

  7. Parenti, A., Aragona, F., Bortuzzo, G., De Caro, R., and Pagano, F., Abnormal Patterns of Mucin Secretion in Ileal Neobladder Mucosa: Evidence of Preneoplastic Lesion?, Eur. Urol., 1999, vol. 35, no. 2, pp. 98–101.

    Article  PubMed  CAS  Google Scholar 

  8. Di Tonno, F., Cassaro, M., Bertoldin, R., Vianello, F., Di Pietro, R., Lavetti, D., and Rugge, M., Colonic Metaplasia in the Long-Term Follow-Up of the Ileal Neobladder, Eur. Urol., 2001, vol. 39, no. 2, pp. 15–18.

    Article  PubMed  Google Scholar 

  9. Stakhovskii, E.A., et al., UA Inventor’s Certificate No. 24870, Byull., 1998, No. 6 (2), p. 3.1.36.

  10. Avtandilov, G.G., Osnovy patologoanatomicheskoi praktiki: Rukovodstvo (Basics of Pathoanatomical Practice: Guidelines) 3rd ed. (extended), Moscow: Ros. Med. Akad. Poslediplom. Obraz., 2007.

    Google Scholar 

  11. Hayat, M.A., Handbook of Immunohistochemistry an in situ Hybridization of Human Carcinomas. Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma, Elsevier: Acad. Press, 2006, vol. 4.

  12. Qtang Liu, Ming Teh, Kosei Ito, Nilesh Shah, Yoshiaki Ito, and Khay Guan Yeoh, CDX2 Expression Is Progressively Decreased in Human Gastric Intestinal Metaplasia, Dysplasia and Cancer, Modern Pathol., 2007, vol. 20, pp. 1286–1297.

    Article  CAS  Google Scholar 

  13. Darienko, R.O., Clinical and Morphological Adaptation of an Artificial Bladder, Cand. Sci. (Med.) Dissertation, St. Petersburg, 2008.

  14. Deev, R.V., Akhmedov, T.A., and Komyakov, B.K., Cell Renewal in the Intestinal Epithelium during Reactive Changes in the Mucous Membrane, Klet. Transplantol. Tkan. Inzhener., 2009, vol. 4, no. 1, pp. 69–73.

    Google Scholar 

  15. Dellis, A.E., Demonakou, M., Papatsoris, A.G., Chrisofos, M., Bamias, A., and Deliveliotis, C., Insight into Long-Term Histological, Proliferative and Apoptotic Modifications in Ileal Orthotopic Neobladder and Conduit Mucosa, Tumori, 2008, vol. 94, no. 5, pp. 701–705.

    PubMed  Google Scholar 

  16. Anichkov, N.M., Darienko, R.O., and Ivantsov, A.O., On the Morphology of an Artificial Bladder, in Aktual’nye voprosy onkourologii (Topical Problems of Oncourology), St. Petersburg, 2005, pp. 23–25.

  17. Nemytin, Yu.V., Sitnikov, N.V., Dronov, V.I., Sidorov, V.A., and Shugaeva, O.B., Morphofunctional Features of the Intestinal Urinary Reservoir, Voen. Med. Zh., 2004, no. 11, pp. 20–26.

  18. Aruin, L.I., Kapuller, L.L., and Isakov, V.A., Morfologicheskaya diagnostika boleznei zheludka i kishechnika (Morphological Diagnostics of Gastric and Intestinal Diseases), Moscow: Triada-Kh, 1998.

    Google Scholar 

  19. Rogachikov, V.V., Morphological Features of Artificial Bladder Depending on the Part of the Intestine That Was Used for Reconstruction, Extended Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 2009.

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Authors and Affiliations

  1. National Institute of Cancer, Ministry of Health, Kiev, Ukraine

    O. I. Iatsyna, Yu. V. Vitruk, S. V. Vernygorodskyi, O. E. Stakhovsky & E. O. Stakhovsky

  2. Institute of Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine

    A. I. Yemets & Ya. B. Blume

Authors
  1. O. I. Iatsyna
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  2. Yu. V. Vitruk
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  3. S. V. Vernygorodskyi
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  4. O. E. Stakhovsky
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  5. A. I. Yemets
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  6. Ya. B. Blume
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  7. E. O. Stakhovsky
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Corresponding author

Correspondence to Ya. B. Blume.

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Original Russian Text © O.I. Iatsyna, Yu.V. Vitruk, S.V. Vernygorodskyi, O.E. Stakhovsky, A.I. Yemets, Ya.B. Blume, E.O. Stakhovsky, 2011, published in Tsitologiya i Genetika, 2011, Vol. 45, No. 6, pp. 3–9.

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Iatsyna, O.I., Vitruk, Y.V., Vernygorodskyi, S.V. et al. Morphological and histochemical analysis of mucous membrane transformation of the artificial urinary bladder. Cytol. Genet. 45, 400–406 (2011). https://doi.org/10.3103/S0095452711060089

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  • DOI: https://doi.org/10.3103/S0095452711060089

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