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Notch122, mutation of Abruptex-type Notch locus in Drosophila virilis: Peculiarities of genetic interactions

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Abstract

The nature and functional peculiarities of Abruptex-type Notch alleles are not yet known. A high level of phenotypic allele polymorphism has been found in Drosophila in known Abruptex lines. In addition to mutants with a lack of Notch function, there are hypomorphic, hypermorphic, and antimorphic alleles that often show enhanced cell proliferation and the failure of processes of cell differentiation in wings. It is considered that Abruptex alleles can serve as a model for studying the reasons for and consequences of hereditary diseases in humans, including CADASIL, which, as is supposed, is related to modifications in Notch activity and gene interactions in the Notch signal system.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, Ukrainian National Academy of Sciences, Kiev, Ukraine

    I. S. Gubenko & R. P. Subbota

  2. Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

    E. S. Zelentsova

Authors
  1. I. S. Gubenko
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  2. R. P. Subbota
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  3. E. S. Zelentsova
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Correspondence to E. S. Zelentsova.

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Original Russian Text © I.S. Gubenko, R.P. Subbota, E.S. Zelentsova, 2010, published in Tsitologiya i Genetika, 2010, Vol. 44, No. 3, pp. 53–57.

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Gubenko, I.S., Subbota, R.P. & Zelentsova, E.S. Notch122, mutation of Abruptex-type Notch locus in Drosophila virilis: Peculiarities of genetic interactions. Cytol. Genet. 44, 170–173 (2010). https://doi.org/10.3103/S0095452710030084

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  • DOI: https://doi.org/10.3103/S0095452710030084

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