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CAG polymorphism of the androgen receptor gene in azoospermic and oligozoospermic men from Ukraine

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Abstract

An analysis of the number of CAG repeats in exon 1 of the gene was conducted in a group of 228 infertile males with azoospermia (n = 68) and oligozoospermia (n = 160), and in a control group (124 proven fathers) by means of polymerase chain reaction with subsequent fragment analysis on an ALF-Express automated fluorescent analyzer. Allele frequency with the number of CAG repeats ≤ 18 was found to be significantly higher (P < 0.01) in the group of patients with azoospermia (17.7%) as compared to the control group (2.4%), and in the group of patients with oligozoospermia (12.5%) as compared to the control group (2.4%). Allele frequency with the number of CAG repeats ≥ 28 was shown to be significantly higher (P < 0.01) in patients with oligozoospermia (12.5%) as compared to the control group (2.4%). Our data suggest an association between the number of CAG repeats and impaired spermatogenesis in azoospermic and oligozoospermic males.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, Ukraine National Academy of Sciences, Kiev, 252143, Ukraine

    O. A. Fesai, S. A. Kravchenko, G. V. Makuh & L. A. Livshits

  2. Institute of Hereditary Pathology, Ukraine Academy of Medical Sciences, Lviv, 79000, Ukraine

    M. Ya. Tyrkus

  3. ISIDA-IVF Clinic, Kiev, 03126, Ukraine

    V. M. Zinchenko

  4. Viktoriya Clinic, Kiev, Ukraine

    G. V. Strelko

Authors
  1. O. A. Fesai
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  2. S. A. Kravchenko
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  3. M. Ya. Tyrkus
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  4. G. V. Makuh
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  5. V. M. Zinchenko
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  6. G. V. Strelko
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  7. L. A. Livshits
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Additional information

Original Russian Text © O.A. Fesai, S.A. Kravchenko, M.Ya. Tyrkus, G.V. Makuh, V.M. Zinchenko, G.V. Strelko, L.A. Livshits, 2009, published in Tsitologiya i Genetika, 2009, Vol. 43, No. 6, pp. 45–51.

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Fesai, O.A., Kravchenko, S.A., Tyrkus, M.Y. et al. CAG polymorphism of the androgen receptor gene in azoospermic and oligozoospermic men from Ukraine. Cytol. Genet. 43, 401–405 (2009). https://doi.org/10.3103/S0095452709060061

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  • DOI: https://doi.org/10.3103/S0095452709060061

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