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Modulators of activity of regulatory proteins acting at ultra low doses

Abstract

New, previously unstudied bioregulators active at ultra low doses, 108 to 10−17 mg protein/ml, were isolated from vitreoretinal tissue. It was shown that these bioregulators contained regulatory peptides and modulators, represented by proteins with a molecular weight of 15–70 kDa, including blood serum albumin. The nanosize of the bioregulators correlated with their activity at ultra low doses.

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Correspondence to V. P. Yamskova.

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Original Russian Text © V.P. Yamskova, M.S. Krasnov, V.S. Skripnikova, A.A. Molyavka, A.P. Il’ina, D.V. Margasyuk, A.V. Borisenko, B.B. Berezin, I.A. Yamskov, 2009, published in Tsitologiya i Genetika, 2009, Vol. 43, No. 6, pp. 28–39.

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Yamskova, V.P., Krasnov, M.S., Skripnikova, V.S. et al. Modulators of activity of regulatory proteins acting at ultra low doses. Cytol. Genet. 43, 387 (2009). https://doi.org/10.3103/S0095452709060048

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Keywords

  • Circular Dichroism Spectrum
  • Ammonium Sulfate
  • Hydrodynamic Radius
  • High Performance Liquid Chromatog
  • Ultralow Dose