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Modulators of activity of regulatory proteins acting at ultra low doses

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Abstract

New, previously unstudied bioregulators active at ultra low doses, 108 to 10−17 mg protein/ml, were isolated from vitreoretinal tissue. It was shown that these bioregulators contained regulatory peptides and modulators, represented by proteins with a molecular weight of 15–70 kDa, including blood serum albumin. The nanosize of the bioregulators correlated with their activity at ultra low doses.

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References

  1. Yamskova, V.P., Modyanova, E.A., Reznikova, M.M., and Malenkov, A.G., Highly Active Tissue-Specific Adhesion Factors of the Liver and Lung, Mol. Biol. (Moscow), 1977, vol. 11, pp. 1147–1154.

    CAS  Google Scholar 

  2. Yamskova, V.P. and Reznikova, M.M., Low-Molecular-Weight Peptide from the Blood Serum of Homeothermic Animals: Effect on Cell Adhesion and Proliferation, Zh. Obshch. Biol., 1991, vol. 52, pp. 181–191.

    CAS  Google Scholar 

  3. Yamskaya, I.A., Yamskova, V.P., Danilenko, A.N., Klemenkova, Z.S., Antipov, B.G., Chernikov, F.R., Gusynina, M.M., and Rybakova, E.Yu., Experimental Proofs of the Role of Physicochemical Factors in the Mechanism of Biological Effect of Ultralow Doses, Ros. Khim. Zhurn. Ros. Khim. Obshch. Im. D.I. Mendeleeva, 1999, vol. 43, no. 5, pp. 34–39.

    Google Scholar 

  4. Krasnov, M.S., Grigoryan, E.N., Yamskova, V.P., Boguslavskii, D.V., and Yamskov, I.A., Regulatory Proteins of Eye Tissues of Vertebrates, Radiats. Biol. Radioekol., 2003, issue 3, pp. 265–268.

  5. Yamskova, V.P., Rybakova, E.Yu., Vecherkin, V.V., Berezin, B.B., Filatova, A.G., Blagodatskikh, I.V., and Yamskov, I.A., in Biochemical Physics Frontal Research, Varfolomeev, S.D., Bulgakova, E.B., Popov, A.A., and Zaikov, G.E., Eds., New York: Nova Sci. Publ. Inc., 2007, pp. 61–70.

    Google Scholar 

  6. Nazarova, P.A., Yamskova, V.P., Krasnov, M.S., Filatova, A.G., and Yamskov, I.A, in New Trends in Biochemical Physics Research, Varfolomeev, S.D., et al., Eds., New York: Nova Sci. Publ. Inc., 2007. P. 73–82.

    Google Scholar 

  7. Borisenko, A.V., Yamskova, V.P., Krasnov, M.S., Blagodatskikh, I.V., Vecherkin, V.V., and Yamskov, I.A., in Biochemical Physics Frontal Research, Varfolomeev, S.D., et al., Eds., New York: Nova Sci. Publ. Inc., 2007, P. 35–45.

    Google Scholar 

  8. Margasyuk, D.V., Krasnov, M.S., Blagodatskikh, I.V., Grigoryan, E.N., Yamskova, V.P., and Yamskov, I.A., in Biochemical Physics Frontal Research, Varfolomeev, S.D., et al., Eds., New York: Nova Sci. Publ. Inc., 2007, pp. 47–59.

    Google Scholar 

  9. Yamskova, V.P., Rybakova, E.Yu., Vinogradov, A.A., Vecherkin, V.V., and Yamskov, I.A., A Study of the Adhesive Glycoprotein-Inactivating Protein from Mammalian Blood Serum, Prikl. Biokhim. Mikrobiol., 2004, vol. 40, no. 4, pp. 407–413.

    Google Scholar 

  10. Yamskova, V.P. and Yamskov, I.A., Mechanism of Biological Effect of Physicochemical Factors in Ultralow Doses, Ros. Khim. Zhurn. Ros. Khim. Obshch. Im. D.I. Mendeleeva, 1999, vol. 43, no. 2, pp. 74–79.

    CAS  Google Scholar 

  11. Krasnov, M.S., Grigoryan, E.N., and Yamskova, V.P., An Organotypic Culture of the Newt Retina together with Other Tissues of the Posterior Eye Segment as a Model for Studying the Effects of Cell Adhesion Glycoproteins, Izv. Akad. Nauk, Ser. Biol., 2003, vol. 30,issue 1, pp. 22–36.

    Google Scholar 

  12. Stepanek, P., Dynamic Light Scattering. The Method and Some Applications, Brown, W., Ed., Oxford: Clarendron Press, 1993.

    Google Scholar 

  13. Filonov, A.S., Gavrilko, D.Yu., and Yaminskii, I.V., Programmnoe obespechenie dlya obrabotki trekhmernykh izobrazhenii “FemtoSkan Onlain” (FemtoSkan Onlain Software for Processing Three-Dimensional Images), Moscow: Tsentr perspektivnykh tekhnologii, 2005.

    Google Scholar 

  14. Laemmli, U.K., Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, 1970, vol. 227, pp. 680–685.

    Article  CAS  PubMed  Google Scholar 

  15. Yamskova, V.P., The Role of Calcium Ions in the Stabilization of Rat Liver Adhesion Factor, Biofizika, 1978, vol. 23, pp. 428–432.

    CAS  Google Scholar 

  16. Krasnov, M.S., Gurmizov, E.P., Yamskova, V.P., and Yamskov, I.A., in Biochemical Physics Frontal Research, Varfolomeev, S.D., et al., Eds., New York: Nova Sci. Publ. Inc., 2007, pp. 21–33.

    Google Scholar 

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Correspondence to V. P. Yamskova.

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Original Russian Text © V.P. Yamskova, M.S. Krasnov, V.S. Skripnikova, A.A. Molyavka, A.P. Il’ina, D.V. Margasyuk, A.V. Borisenko, B.B. Berezin, I.A. Yamskov, 2009, published in Tsitologiya i Genetika, 2009, Vol. 43, No. 6, pp. 28–39.

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Yamskova, V.P., Krasnov, M.S., Skripnikova, V.S. et al. Modulators of activity of regulatory proteins acting at ultra low doses. Cytol. Genet. 43, 387–395 (2009). https://doi.org/10.3103/S0095452709060048

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  • DOI: https://doi.org/10.3103/S0095452709060048

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