Frequency of Pro12Ala-polymorphism of the gene PPARγ2 in the Ukrainian population and its possible relation to the development of the metabolic syndrome
The distribution of Pro12Ala polymorphism is studied for the first time in the Ukrainian population, using 39 healthy individuals and 42 male subjects aged 40–65 with symptoms of the metabolic syndrome. The frequency of the allele 12Ala is found to be 27.4%, that of the Pro12Ala genotype, 32.6%, and that of the Ala12Ala genotype, 4.4%. These figures are close to the results found for the Czech population. Among individuals with the metabolic syndrome the frequency of the allele 12Ala is reliably less, or 18.4%, which corresponds to previously established data on individuals with Type 2 diabetes mellitus. A trend towards increasing body mass index among individuals with the 12Ala allele is found in the group of patients with symptoms of the metabolic syndrome.
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