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Bacterial test system for the primary screening of substances with potential antitumor activity

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Abstract

A fundamental possibility of antitumor activity testing in the bacterial system represented by Escherichia coli of the wild type and its MS2-induced mutant has been shown. The initial bacterial strain is an indicator of toxic properties of tested substances and the mutant strain is a specific test culture modeling a tumor cell. The comparison of the data described for eukaryotes with the data obtained using the proposed bacterial test system confirms an adequate response of both strains to substances with proved antitumor properties. The data obtained are considered as very promising for the further improvement of this test system towards its application for primary screening of antitumor substances.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, ul. Zabolotnogo 150, Kiev, 03143, Ukraine

    T. P. Pererva, A. S. Dvornyk, A. Yu. Miryuta, L. P. Mozhylevska & V. A. Kunakh

Authors
  1. T. P. Pererva
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  2. A. S. Dvornyk
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  3. A. Yu. Miryuta
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  4. L. P. Mozhylevska
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  5. V. A. Kunakh
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Additional information

Original Russian Text © T.P. Pererva, A.S. Dvornyk, A.Yu. Miryuta, L.P. Mozhylevska, V.A. Kunakh, 2007, published in Tsitologiya i Genetika, 2007, Vol. 41, No. 4, pp. 59–65.

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Pererva, T.P., Dvornyk, A.S., Miryuta, A.Y. et al. Bacterial test system for the primary screening of substances with potential antitumor activity. Cytol. Genet. 41, 245–250 (2007). https://doi.org/10.3103/S009545270704010X

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  • DOI: https://doi.org/10.3103/S009545270704010X

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