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Solubility Study of Amlodipine Besylate in Ethylene Glycol + 2-Propanol Mixtures at Different Temperatures

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Moscow University Chemistry Bulletin Aims and scope

Abstract

Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.

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REFERENCES

  1. Burges, R. and Moisey, D., Am. J. Cardiol., 1994, vol. 73, p. A2.

    Article  Google Scholar 

  2. Rollinger, J. and Burger, A., J. Therm. Anal. Calorim., 2002, vol. 68, p. 361.

    Article  CAS  Google Scholar 

  3. Abernethy, D.R. and Schwartz, J.B., New Engl. J. Med., 1999, vol. 341, p. 1447.

    Article  CAS  PubMed  Google Scholar 

  4. Caron, G., Ermondi, G., Damiano, A., Novaroli, L., Tsinman, O., Ruell, J.A., and Avdeef, A., Bioorg. Med. Chem., 2004, vol. 12, p. 6107.

    Article  CAS  PubMed  Google Scholar 

  5. Amidon, G.L., Lennernäs, H., Shah, V.P., and Crison, J.R., Pharm. Res., 1995, vol. 12, p. 413.

    Article  CAS  PubMed  Google Scholar 

  6. Ain, S., Ain, Q., and Parveen, S., Pharma Res., 2009, vol. 2, p. 84.

    Google Scholar 

  7. Vemula, V.R., Lagishetty, V., and Lingala, S., Int. J. Pharm. Sci. Rev. Res., 2010, vol. 5, p. 41.

    CAS  Google Scholar 

  8. Jouyban, A., Handbook of Solubility Data for Pharmaceuticals, Boca Raton: CRC, 2009.

    Book  Google Scholar 

  9. Behboudi, E., Soleymani, J., Martinez, F., and Jouyban, A., J. Mol. Liq., 2022, vol. 347, p. 118394.

    Article  CAS  Google Scholar 

  10. Sardari, F. and Jouyban, A., J. Chem. Eng. Data, 2012, vol. 57, p. 2848.

    Article  CAS  Google Scholar 

  11. Jouyban, A., J. Pharm. Pharm. Sci., 2019, vol. 22, p. 466.

    Article  CAS  PubMed  Google Scholar 

  12. Jouyban-Gharamaleki, A., Valaee, L., Barzegar-Jalali, M., Clark, B., and Acree, W., Jr., Int. J. Pharm., 1999, vol. 177, p. 93.

    Article  CAS  PubMed  Google Scholar 

  13. Ruidiaz, M.A., Rodríguez, S.J., Neita, P.C., Cristancho, D.M., and Martínez, R.F., Vitae, 2010, vol. 17, p. 309.

    Article  Google Scholar 

  14. Jouyban, A., Fakhree, M.A.A., and Acree, W., Jr., Toxicity and Drug Testing, New York: Intech, 2012.

    Google Scholar 

  15. Grant, D., Mehdizadeh, M., Chow A.-L., and Fairbrother, J., Int. J. Pharm., 1984, vol. 18, p. 25.

    Article  CAS  Google Scholar 

  16. Acree, W.E., Jr., Thermochim. Acta, 1992, vol. 198, p. 71.

    Article  CAS  Google Scholar 

  17. Jouyban, A. and Acree, W.E., Jr., J. Mol. Liq., 2018, vol. 256, p. 541.

    Article  CAS  Google Scholar 

  18. Ochsner, A.B., Belloto, R.J., Jr., and Sokoloski, T.D., J. Pharm. Sci., 1985, vol. 74, p. 132.

    Article  CAS  PubMed  Google Scholar 

  19. Buchowski, H., Ksiazczak, A., and Pietrzyk, S., J. Phys. Chem., 1980, vol. 84, p. 975.

    Article  CAS  Google Scholar 

  20. Buchowski, H. and Khiat, A., Fluid Phase Equilib., 1986, vol. 25, p. 273.

    Article  CAS  Google Scholar 

  21. Jouyban-Gharamaleki, A., Chem. Pharm. Bull., 1998, vol. 46, p. 1058.

    Article  CAS  Google Scholar 

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Funding

The research reported in this publication was supported by the Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran under grant no. 67769.

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Authors and Affiliations

  1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Homa Rezaei

  2. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Homa Rezaei, Abolghasem Jouyban & Elaheh Rahimpour

  3. Department of Chemistry, Arts and Science Faculty, Suleyman Demirel University, 32260, Isparta, Turkey

    Kader Poturcu

  4. Faculty of Pharmacy, Near East University, 99138, Nicosia, North Cyprus, Turkey

    Abolghasem Jouyban

  5. College of Chemistry and Chemical Engineering, YangZhou University, 225002, YangZhou, Jiangsu, People’s Republic of China

    Hongkun Zhao

  6. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Elaheh Rahimpour

Authors
  1. Homa Rezaei
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  2. Kader Poturcu
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  3. Abolghasem Jouyban
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  4. Hongkun Zhao
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  5. Elaheh Rahimpour
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Corresponding author

Correspondence to Elaheh Rahimpour.

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The authors of this work declare that they have no conflicts of interest.

ABBREVIATIONS

ADB, amlodipine besylate; CNIBS, combined nearly ideal binary solvent; EG, ethylene glycol; MRS, mixture response surface; MRD, mean relative deviation.

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Homa Rezaei, Poturcu, K., Jouyban, A. et al. Solubility Study of Amlodipine Besylate in Ethylene Glycol + 2-Propanol Mixtures at Different Temperatures. Moscow Univ. Chem. Bull. 79, 72–78 (2024). https://doi.org/10.3103/S0027131424010048

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  • DOI: https://doi.org/10.3103/S0027131424010048

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