Moscow University Chemistry Bulletin

, Volume 71, Issue 5–6, pp 312–318 | Cite as

Study on metronidazole distribution in rectal cancer tissue using application method of administration in experiment in vivo

  • S. A. Yagubov
  • G. M. Yankovskii
  • S. E. Kondakov


The distribution of metronidazole in rectal cancer tissue using application method of administration was studied. A comparative evaluation of pharmacokinetic parameters of metronidazole accumulation in the tissues depending on the concentration of the drug in the application mixture was carried out. The generalized actual data on metronidazole distribution in tissue samples (341 sample) obtained during 31 surgery are presented.


metronidazole cancer tissues bioavailability in vivo experiment 


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Copyright information

© Allerton Press, Inc. 2016

Authors and Affiliations

  • S. A. Yagubov
    • 1
  • G. M. Yankovskii
    • 1
  • S. E. Kondakov
    • 2
  1. 1.Blokhin Russian Cancer Research CenterMoscowRussia
  2. 2.Department of ChemistryMoscow State UniversityMoscowRussia

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