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Conformational fingerprinting of angiotensin-converting enzyme in the blood in health and disease

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The binding pattern of the set of 16 monoclonal antibodies to the different epitopes on the surface of two domains of angiotensin-converting enzyme, i.e., conformational fingerprinting, allows to reveal in blood the presence of an enzyme that is not produced by lung endothelial cells, but rather by other cells, e.g., Gaucher’s cells and sarcoid granuloma cells. The existence of angiotensin-converting enzyme with changed conformation in the blood of patients with uremia has been shown; this enzyme was characterized by enhanced activity towards angiotensin I and decreased ability to be inhibited by specific inhibitors. The prospects of discovering conformationally changed enzyme in blood of patients with atrial fibrillation have also been discussed.

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Authors and Affiliations

  1. Department of Chemical Enzymology, Faculty of Chemistry, Moscow State University, Moscow, Russia

    O. A. Kost, M. N. Petrov, I. A. Naperova, V. A. Tikhomirova, O. V. Kryukova & I. V. Gachok

  2. Bakulev Research Center for Cardiovascular Surgery, Moscow, Russia

    N. I. Bulaeva & E. Z. Golukhova

  3. University of Illinois, Chicago, USA

    S. M. Danilov

Authors
  1. O. A. Kost
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  2. M. N. Petrov
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  3. I. A. Naperova
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  4. V. A. Tikhomirova
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  5. O. V. Kryukova
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  6. I. V. Gachok
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  7. N. I. Bulaeva
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  8. E. Z. Golukhova
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  9. S. M. Danilov
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Corresponding author

Correspondence to O. A. Kost.

Additional information

Original Russian Text © O.A. Kost, M.N. Petrov, I.A. Naperova, V.A. Tikhomirova, O.V. Kryukova, I.V. Gachok, N.I. Bulaeva, E.Z. Golukhova, S.M. Danilov, 2015, published in Vestnik Moskovskogo Universiteta. Khimiya, 2015, No. 6, pp. 399–404.

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Kost, O.A., Petrov, M.N., Naperova, I.A. et al. Conformational fingerprinting of angiotensin-converting enzyme in the blood in health and disease. Moscow Univ. Chem. Bull. 71, 32–36 (2016). https://doi.org/10.3103/S0027131416010089

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  • DOI: https://doi.org/10.3103/S0027131416010089

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