Moscow University Chemistry Bulletin

, Volume 69, Issue 3, pp 112–116 | Cite as

An investigation of the physicochemical properties of both glutathione peroxidase I and its complexes with polyelectrolytes as promising agents for the treatment of diseases of the central nervous system

  • I. S. Panina
  • L. Y. Filatova
  • A. V. Kabanov
  • N. L. Klyachko


A study of the kinetics of the thermal inactivation of glutathione peroxidase I was carried out. Glutathione peroxidase is an enzyme that plays a key role in the antioxidant protection system of the body. It was shown that oligomeric glutathione peroxidase I is inactivated by a monomolecular mechanism (37°C, pH 7.0, the enzyme concentrations 0.3 and 1 mg/mL). An effective method for stabilizing the enzyme by polyelectrolytes of different natures was proposed.


reactive oxygen species glutathione peroxidase I polyelectrolyte kinetics of inactivation stabilization 


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Copyright information

© Allerton Press, Inc. 2014

Authors and Affiliations

  • I. S. Panina
    • 1
  • L. Y. Filatova
    • 1
  • A. V. Kabanov
    • 1
    • 2
  • N. L. Klyachko
    • 1
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia
  2. 2.The Center for Nanotechnology in Drug Delivery, Carolina Institute for NanomedicineUniversity of North CarolinaChapel HillUSA

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