Physics of Wave Phenomena

, Volume 19, Issue 1, pp 62–67 | Cite as

Simulation of thermal lesions in biological tissues irradiated by high-intensity focused ultrasound through the rib cage

  • S. A. Ilyin
  • S. M. Bobkova
  • V. A. Khokhlova
  • L. R. Gavrilov


Thermal effect of high-intensity focused ultrasound on biological tissue behind the rib cage phantom has been numerically simulated. A phased array was used as a source of ultrasound. Temperature and thermal dose distributions in the biological tissue were calculated and used to find the form of thermal lesions. The results of the calculations are in good agreement with experiment and show that the model is applicable for predicting the effect produced by ultrasound in tissue.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C. Hill, J. Bamber, and G. ter Haar, Physical Principles of Medical Ultrasonics, 2nd ed. (Wiley, Chichester, 2004).CrossRefGoogle Scholar
  2. 2.
    M. R. Bailey, V. A. Khokhlova, O. A. Sapozhnikov, S. G. Kargl, and L.A. Crum, “Physical Mechanisms of the Therapeutic Effect of Ultrasound (A Review),” Acoust. Phys. 49(4), 369 (2003).ADSCrossRefGoogle Scholar
  3. 3.
    F. Li, X. Gong, K. Hu, C. Li, and Z. Wang, “Effect of Ribs in HIFU Beam Path on Formation of Coagulative Necrosis in Goat Liver,” in Proceedings of the Therapeutic Ultrasound: 5th International Symposium on Therapeutic Ultrasound (Boston, Massachusetts, 27–29 October 2005). AIP Conf. Proc. 829, 477 (2006).Google Scholar
  4. 4.
    S. Bobkova, L. Gavrilov, V. Khokhlova, A. Shaw, and J. Hand, “Focusing of High Intensity Ultrasound through the Rib Cage Using Therapeutic Random Phased Array,” Ultrasound in Medicine and Biology. 36(6), 888 (2010).CrossRefGoogle Scholar
  5. 5.
    S. A. Sapareto and W.C. Dewey, “Thermal Dose Determination in Cancer Therapy,” Rad. Oncol. Biol. Phys. 10, 787 (1984).CrossRefGoogle Scholar
  6. 6.
    E. A. Filonenko, L. R. Gavrilov, V. A. Khokhlova, and J.W. Hand, “Heating of Biological Tissues by Two-Dimensional Phased Arrays with Random and Regular Element Distributions,” Acoust. Phys. 50(2), 222 (2004).ADSCrossRefGoogle Scholar
  7. 7.
    F. A. Duck, Physical Properties of Tissue (Academic Press, London, 1990), p. 346.Google Scholar
  8. 8.
    J.W. Hand, A. Shaw, N. Sadhoo, S. Rajagopal, R. J. Dickinson, and L.R. Gavrilov, “A Random Phased Array Device for Delivery of High Intensity Focused Ultrasound,” Phys. Med. Biol. 54, 5675 (2009).CrossRefGoogle Scholar
  9. 9.
    L. R. Gavrilov and J.W. Hand, “A Theoretical Assessment of the Relative Performance of Spherical Phased Arrays for Ultrasound Surgery and Therapy,” IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 41(1), 125 (2000).CrossRefGoogle Scholar
  10. 10.
    E. S. Ebbini and C.A. Cain, “Multiple-Focus Ultrasound Phased Array Pattern Synthesis: Optimal Driving Signal Distributions for Hyperthermia,” IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 36(5), 540 (1989).CrossRefGoogle Scholar
  11. 11.
    S. A. Goss, L. A. Frizzell, J. T. Kouzmanoff, J.M. Barich, and J. M. Yang, “Sparse Random Ultrasound Phased Array for Focal Surgery,” IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 43(6), 1111 (1996).CrossRefGoogle Scholar

Copyright information

© Allerton Press, Inc. 2011

Authors and Affiliations

  • S. A. Ilyin
    • 1
  • S. M. Bobkova
    • 1
  • V. A. Khokhlova
    • 1
  • L. R. Gavrilov
    • 2
  1. 1.Lomonosov Moscow Sate UniversityMoscowRussia
  2. 2.Andreyev Acoustics InstituteRussian Academy of SciencesMoscowRussia

Personalised recommendations