Russian Agricultural Sciences

, Volume 45, Issue 5, pp 487–491 | Cite as

Prognostic Value for Parameters of the Hemostasis System during Parvovirus Infection of Carnivores

  • E. S. Baruzdina
  • E. N. SobolevaEmail author

Abstract—Prognostic significance of the hemostasis system’s parameters in dogs with parvovirus infection has been evaluated. Blood test results of dead (n = 4) and surviving dogs (n = 11) on the third and fifth day of illness at 2–6-months of age were compared with each other and with results from the blood test of healthy dogs in the control group (n = 10). By the third day of the disease, as markers of an unfavorable prognosis, one can distinguish a decrease in platelet count to 285.97 ± 14.84 × 109/L, an increase in the average platelet volume to 8.5 ± 1.7 fl, and platelet survival time (PST) to 0.53 ± 0.02%, summing up of the platelet aggregation index with ADP induction aggregators to 131.67 ± 9.28% and ristomycin to 127.77 ± 14.71%, a decrease in disaggregation with ADP aggregation inducers to 1.03 ± 1.03% and ristomycin to 0.08 ± 0.08%, an increase in the amount of fibrinogen to 5.2 ± 0.49 g/L and soluble fibrin-monomer complexes to 12.97 ± 1.15 mg/100 mL with a decrease in antithrombin activity to 105.3 ± 3.16%. By the fifth day of illness, the risk of death is associated with such parameters as a progressive decrease in platelet count to 227 ± 15.64 × 109/L with a decrease in the average platelet volume to 5.5 ± 1.2 fl as well as PST to 0.21 ± 0.03% with a summing platelet aggregation index with ADP aggregation inducers to 31.67 ± 12.03%, with collagen to 15.53 ± 4.26%, and ristomycin to 14.8 ± 5.6%; a decrease in disaggregation with ADP by 81%, with collagen by 77%, and with ristomycin by 98.7%; an increase in prothrombin time from 14.17 ± 0.24 to 18.5 ± 2.9 s, thrombin time from 9.07 ± 0.58 to 15.3 ± 2.08 s, and activated partial thromboplastin time from 18.03 ± 1.54 to 26.37 ± 1.57 s as well as soluble fibrin-monomer complexes to 17.3 ± 1.17 mg/100 mL; a decrease in the amount of fibrinogen to 2.73 ± 0.89 g/L and antithrombin activity to 88.63 ± 14.93%.

Keywords: plasma-coagulation hemostasis platelet hemostasis prognostic markers dogs parvovirus enteritis 



This article does not contain any studies involving human participants performed by any of the authors.

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.


The authors declare that they have no conflicts of interest.


  1. 1.
    Vlasov, N.A., Ulasov, V.I., Chernyaeva, I.S., Elizbarashvili, E.I., Vakhrameeva, V.V., and Vasil’ev, D.A., Parvovirusy plotoyadnykh i vyzyvaemye imi bolezni (Parvoviruses in Carnivores and Related Diseases), Ulyanovsk, 2000.Google Scholar
  2. 2.
    Houston, D.M., Ribble, C.S., and Head, L.L., Risk factors associated with parvovirus enteritis in dogs: 283 cases (1982–1991), J. Am. Vet. Med. Assoc., 1996, vol. 208, no. 4, pp. 542–546.PubMedGoogle Scholar
  3. 3.
    Sulimov, A.A. and Ulasov, V.I., Parvovirus infections of carnivores, Ross. Vet. Zh., Melkie Domashnie Zhivotn., 2008, no. 2, pp. 40–45.Google Scholar
  4. 4.
    Mylonakis, M.E., Kalli, I., and Rallis, T.S., Canine parvoviral enteritis: An update on the clinical diagnosis, treatment, and prevention, Vet. Med. (Auckl.), 2016, vol. 7, pp. 91–100.Google Scholar
  5. 5.
    Goddard, A. and Leisewitz, A.L., Canine parvovirus, Vet. Clin. North Am. Small Anim. Pract., 2010, no. 40, pp. 1041–1053.CrossRefGoogle Scholar
  6. 6.
    Gauthier, V., Effects of tetrastarch administration on hemostatic, laboratory, and hemodynamic variables in healthy dogs and dogs with systemic inflammation, Doctoral (Vet. Sci.) Thesis, Guelph: The University of Guelph, 2013.Google Scholar
  7. 7.
    Baruzdina, E.S., Age-related features of plasma-coagulation hemostasis in dogs with parvovirus infection, Aktual. Vopr. Vet. Biol., 2018, no. 2, pp. 4–10.Google Scholar
  8. 8.
    Otto, C., Rieser, T.M., and Brooks, M.B., Evidence of hipercoagulability in dogs with paгvoviral enteritis, J. Am. Vet. Med. Assoc., 2000, no. 21, pp. 1500–1504.CrossRefGoogle Scholar
  9. 9.
    Kocaturk, M., Martinez, S., Eralp, O., Tvarijonaviciute, A., Ceron, J., and Yilmaz, Z., Prognostic value of serum acute phase proteins in dogs with parvoviral enteritis, J. Small Anim. Pract., 2010, no. 51, pp. 478–483.CrossRefGoogle Scholar
  10. 10.
    Goddard, A., Leisewitz, A.L., Christopher, M.M., Duncan, N.M., and Becker, P.J., Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis, J. Vet. Intern. Med., 2008, no. 22, pp. 309–316.CrossRefGoogle Scholar
  11. 11.
    Schoeman, J.P., Goddard, A., and Leisewitz, A.L., Biomarkers in canine parvovirus enteritis, N. Z. Vet. J., 2013, no. 61, pp. 217–222.CrossRefGoogle Scholar
  12. 12.
    Baruzdina, E.S. and Oshurkova, Yu.L., Features of the functioning of the hemostatic system in healthy dogs aged from two to six months, Aktual. Vopr. Vet. Biol., 2016, no. 3, pp. 8–12.Google Scholar
  13. 13.
    Baluda, V.P., Barkagan, Z.S., and Gol’dberg, E.D., Laboratornye metody issledovaniya sistemy gemostaza (Laboratory Techniques for Studying the Hemostasis System), Tomsk, 1980.Google Scholar
  14. 14.
    Devyatkin, A.V., Clinical significance of microcirculation and hemorheology disorders in influenza and other acute respiratory viral infections in patients with complications and concomitant diseases, Doctoral (Med.) Dissertation, Moscow, 2003.Google Scholar

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© Allerton Press, Inc. 2019

Authors and Affiliations

  1. 1.Vereshchagin Vologda State Dairy Farming AcademyVologdaRussia

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