Prognostic Value for Parameters of the Hemostasis System during Parvovirus Infection of Carnivores
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Abstract—Prognostic significance of the hemostasis system’s parameters in dogs with parvovirus infection has been evaluated. Blood test results of dead (n = 4) and surviving dogs (n = 11) on the third and fifth day of illness at 2–6-months of age were compared with each other and with results from the blood test of healthy dogs in the control group (n = 10). By the third day of the disease, as markers of an unfavorable prognosis, one can distinguish a decrease in platelet count to 285.97 ± 14.84 × 109/L, an increase in the average platelet volume to 8.5 ± 1.7 fl, and platelet survival time (PST) to 0.53 ± 0.02%, summing up of the platelet aggregation index with ADP induction aggregators to 131.67 ± 9.28% and ristomycin to 127.77 ± 14.71%, a decrease in disaggregation with ADP aggregation inducers to 1.03 ± 1.03% and ristomycin to 0.08 ± 0.08%, an increase in the amount of fibrinogen to 5.2 ± 0.49 g/L and soluble fibrin-monomer complexes to 12.97 ± 1.15 mg/100 mL with a decrease in antithrombin activity to 105.3 ± 3.16%. By the fifth day of illness, the risk of death is associated with such parameters as a progressive decrease in platelet count to 227 ± 15.64 × 109/L with a decrease in the average platelet volume to 5.5 ± 1.2 fl as well as PST to 0.21 ± 0.03% with a summing platelet aggregation index with ADP aggregation inducers to 31.67 ± 12.03%, with collagen to 15.53 ± 4.26%, and ristomycin to 14.8 ± 5.6%; a decrease in disaggregation with ADP by 81%, with collagen by 77%, and with ristomycin by 98.7%; an increase in prothrombin time from 14.17 ± 0.24 to 18.5 ± 2.9 s, thrombin time from 9.07 ± 0.58 to 15.3 ± 2.08 s, and activated partial thromboplastin time from 18.03 ± 1.54 to 26.37 ± 1.57 s as well as soluble fibrin-monomer complexes to 17.3 ± 1.17 mg/100 mL; a decrease in the amount of fibrinogen to 2.73 ± 0.89 g/L and antithrombin activity to 88.63 ± 14.93%.
COMPLIANCE WITH ETHICAL STANDARDS
This article does not contain any studies involving human participants performed by any of the authors.
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
CONFLICT OF INTEREST
The authors declare that they have no conflicts of interest.
- 1.Vlasov, N.A., Ulasov, V.I., Chernyaeva, I.S., Elizbarashvili, E.I., Vakhrameeva, V.V., and Vasil’ev, D.A., Parvovirusy plotoyadnykh i vyzyvaemye imi bolezni (Parvoviruses in Carnivores and Related Diseases), Ulyanovsk, 2000.Google Scholar
- 3.Sulimov, A.A. and Ulasov, V.I., Parvovirus infections of carnivores, Ross. Vet. Zh., Melkie Domashnie Zhivotn., 2008, no. 2, pp. 40–45.Google Scholar
- 4.Mylonakis, M.E., Kalli, I., and Rallis, T.S., Canine parvoviral enteritis: An update on the clinical diagnosis, treatment, and prevention, Vet. Med. (Auckl.), 2016, vol. 7, pp. 91–100.Google Scholar
- 6.Gauthier, V., Effects of tetrastarch administration on hemostatic, laboratory, and hemodynamic variables in healthy dogs and dogs with systemic inflammation, Doctoral (Vet. Sci.) Thesis, Guelph: The University of Guelph, 2013.Google Scholar
- 7.Baruzdina, E.S., Age-related features of plasma-coagulation hemostasis in dogs with parvovirus infection, Aktual. Vopr. Vet. Biol., 2018, no. 2, pp. 4–10.Google Scholar
- 12.Baruzdina, E.S. and Oshurkova, Yu.L., Features of the functioning of the hemostatic system in healthy dogs aged from two to six months, Aktual. Vopr. Vet. Biol., 2016, no. 3, pp. 8–12.Google Scholar
- 13.Baluda, V.P., Barkagan, Z.S., and Gol’dberg, E.D., Laboratornye metody issledovaniya sistemy gemostaza (Laboratory Techniques for Studying the Hemostasis System), Tomsk, 1980.Google Scholar
- 14.Devyatkin, A.V., Clinical significance of microcirculation and hemorheology disorders in influenza and other acute respiratory viral infections in patients with complications and concomitant diseases, Doctoral (Med.) Dissertation, Moscow, 2003.Google Scholar