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Bulletin of the Lebedev Physics Institute

, Volume 45, Issue 9, pp 279–281 | Cite as

Mass Spectrometry Profiling of the Protein Composition of Blood Plasma of Colorectal Cancer Patients

  • A. L. Kaysheva
  • A. T. Kopylov
  • T. O. Pleshakova
  • N. E. Kushlinskii
  • V. G. Nikitaev
  • E. A. Druzhinina
  • A. I. Archakov
  • Yu. D. Ivanov
Article
  • 15 Downloads

Abstract

The objective of the study is themass spectrometry analysis of the protein composition in blood plasma samples of large intestine cancer patients. Protein profiles of 58 blood plasma samples of large intestine cancer patients and healthy volunteers are analyzed using ultrahigh-resolution panoramic mass spectrometry. It is shown that the coincidence of identifications in the protein composition samples of intestine cancer patients and healthy men is 60–80%. Samples of intestines cancer patients contain proteins involved in the interaction with ribonucleic acid, proteins, and lowmolecular substrata.

Keywords

liquid chromatography–mass spectrometry panoramic analysis protein profile colorectal cancer 

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Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  • A. L. Kaysheva
    • 1
  • A. T. Kopylov
    • 1
  • T. O. Pleshakova
    • 1
  • N. E. Kushlinskii
    • 2
  • V. G. Nikitaev
    • 3
  • E. A. Druzhinina
    • 3
  • A. I. Archakov
    • 1
  • Yu. D. Ivanov
    • 1
  1. 1.Institute of Biomedical ChemistryMoscowRussia
  2. 2.N. N. Blokhin National Medical Research Centre of OncologyMoscowRussia
  3. 3.National Research Nuclear University “MEPhI”MoscowRussia

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