Fetal valproate syndrome as an experimental model of autism

  • A. V. Malyshev
  • K. R. Abbasova
  • O. A. Averina
  • L. N. Solovieva
  • V. R. Gedzun
  • M. V. Gulyaev
  • V. A. Dubynin


High doses of valproic acid (VPA) can modify the activity of many genes by blocking histone deacetylases. Prenatal administration of VPA results in the development of fetal valproate syndrome in the offspring of laboratory animals. This syndrome is considered as a model of autism spectrum disorders. In this review, we discuss the characteristics of the brain state and activity during fetal valproate syndrome at different levels: from the molecular and cellular processes to the behavior. The characteristics of social interaction—the most relevant manifestations of autistic disorders—receive special attention. We present literature data and our own results.


autism spectrum disorder valproic acid animal models social behavior review 


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Copyright information

© Allerton Press, Inc. 2015

Authors and Affiliations

  • A. V. Malyshev
    • 1
  • K. R. Abbasova
    • 1
  • O. A. Averina
    • 2
  • L. N. Solovieva
    • 1
  • V. R. Gedzun
    • 1
  • M. V. Gulyaev
    • 3
  • V. A. Dubynin
    • 1
  1. 1.Department of BiologyMoscow State UniversityMoscowRussia
  2. 2.Experimental Vivarium Complex of Research Institute of MitoengineeringMoscow State UniversityMoscowRussia
  3. 3.Center for Magnetic Tomography and SpectroscopyMoscow State UniversityMoscowRussia

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