Behavioral effect of soymorphin-5-amide in rats
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Behavioral effects of YPFVV-NH2 (an analogue of soymorphin-5, an exorphin derived from a soy protein) in rats were investigated for the first time. Rats of different sex and age were tested. It was shown that the stimulation of locomotion in adult rats (males) was the main effect of the peptide injection. In juvenile rats, in turn, the main effect of YPFVV-NH2 was related to anxiety. The anxiolytic effect superseded the anxiogenic effect during puberty. Finally, the manifestation of the peptide effects depended on animals’ stress level.
Keywordssoymorphin locomotion anxiety
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