Biochemical changes in blood at lead intoxication and pectin correction

  • L. V. Kuzmicheva
  • E. A. Lopatnikova
  • G. V. MaksimovEmail author


The results of changes in liver biochemical parameters (AST, ALT, alkaline phosphatase, total protein, urea, and bilirubin) indicating the presence and type of liver injury in lead intoxication and subsequent correction with pectin.


intoxication lead pectin liver pathology complexation 


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  1. 1.
    Bekkelman, I. and Pfister, E., Neurotoxicity due to long-standing exposure to lead, Med. Tr. Prom. Ekol., 2001, no. 5, pp. 22–25.Google Scholar
  2. 2.
    Korbakova, A.I., Sorkina, N.S., Molodkina, N.N., Ermolenko, A.E., and Veselovskaya, K.A., Lead and Its Effects on the Organism, Med. Tr. Prom. Ekol., 2001, no. 5, pp. 29–34.Google Scholar
  3. 3.
    Mehendale, H.M., Calpain: a death protein that mediates progression of liver injury, Trends Pharmacol. Sci., 2005, vol. 26, no. 5, pp. 232–236.PubMedCrossRefGoogle Scholar
  4. 4.
    Occupational health, e-Gohnet Newslett, 2001, vol. 1, pp. 7–11.Google Scholar
  5. 5.
    Medik, V.A., Modern approaches to the study of morbidity of population, Probl. Sots. Gig. Zdravookhr. Istor. Med., 2004, no. 1, pp. 6–9.Google Scholar
  6. 6.
    Zeng, R.S., Niu, G., Wen, Z., Schuler, M.A., and Berenbaum, M.R., Toxicity of aflatoxin Bl to Helicoverpazea and bioactivation by cytochrome P450 monooxygenases, J. Chem. Ecol., 2006, vol. 32, no. 7, pp. 1459–1471.PubMedCrossRefGoogle Scholar
  7. 7.
    Chandra Mohan, K.V., Kumaraguruparan, R., Prathiba, D., and Nagini, S., Modulation of xenobiotic-metabolizing enzymes and redox status during chemoprevention of hamster buccal carcinogenesis by bovine lactoferrin, Nutrition, 2006, vol. 22, no. 9, pp. 940–946.PubMedCrossRefGoogle Scholar
  8. 8.
    Vasilenko, Yu.K. and Kaisheva, N.Sh., The mechanism of detoxifying action of polysaccharides in lead intoxication, Khim.-Farmakol. Zh., 2003, vol. 37, no. 4, pp. 12–15.Google Scholar
  9. 9.
    Khotimchenko, M., Sergushchenko, I., and Khotimchenko, Y., The effects of low-esterified pectin on leadinduced thyroid injury in rats, Environ. Toxicol. Pharmacol., 2004, vol. 17, pp. 67–71.PubMedCrossRefGoogle Scholar
  10. 10.
    Fujisawa, G., Muto, S., Okada, K., Kusano, E., and Ishibashi, S., Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats, Transl. Res., 2006, vol. 148, no. 3, pp. 149–156.PubMedCrossRefGoogle Scholar
  11. 11.
    Gichev, Yu.P., Sovremennye problemy ekologicheskoi meditsiny (Modern Problems of Environmental Medicine), Novosibirsk, 1999.Google Scholar
  12. 12.
    Khotimchenko, Yu.S., Odintsova, M.V., and Kovalev, V.V., Polisorbovit (Polysorbovit), Tomsk: Izd. Nauchn.Tekhn. Lit., 2001.Google Scholar
  13. 13.
    Khotimchenko, Yu.S. and Sergushchenko, I.S., Comparative efficiency of low-esterified pectin and antistrumin during experimental hyperfunction of the thyroid gland, Bull. Exp. Biol. Med., 2003, vol. 136, no. 6, pp. 566–568.PubMedCrossRefGoogle Scholar
  14. 14.
    Khotimchenko, Yu.S., Kropotov, A.V., and Khotimchenko, M.Yu., Pharmacological Properties of Pectin, Efferent. Ter., 2001, vol. 7, no. 4, pp. 22–36.Google Scholar
  15. 15.
    Garcia-Diez, F., Garcia-Mediavilla, V., Bayon, J.E., and Gonzalez-Gallego, J., Pectin feeding influences fecal bile acid excretion, hepatic bile acid and cholesterol synthesis and serum cholesterol in rats, J. Nutr., 1996, vol. 126, no. 7, pp. 1766–1771.PubMedGoogle Scholar
  16. 16.
    Lazebnik, L.B., Zvenigorodskaya, L.A., Moroz, I.A., and Shepeleva, S.D., Clinico-morphological changes in the liver in atherogenic dyslipidemia and in statin treatment, Ter. Arkh., 2003, no. 8, pp. 51–55.Google Scholar
  17. 17.
    Lopatnikova, E.G., Kuz’micheva, L.V., and Al’ba, N.V., Efficacy of pectins in intoxication with heavy metals, in Tez. 14-i Mezhdunar. Pushchinskoi shkoly-konferentsii molodykh uchenykh “Biologiya — nauka XXI veka” (Proc. 14th Int. Pushchino School-Conference of Young Scientists “Biology-Science of the XXI century”), Pushchino, 2010, p. 39.Google Scholar
  18. 18.
    Komissarenko, S.N. and Spiridonov, V.N., Pectins: properties and applications, Rastit. Resur., 1998, no. 1, pp. 111–119.Google Scholar

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© Allerton Press, Inc. 2014

Authors and Affiliations

  • L. V. Kuzmicheva
    • 1
  • E. A. Lopatnikova
    • 1
  • G. V. Maksimov
    • 1
    Email author
  1. 1.Department of BiophysicsOgarev Mordovia State UniversitySaransk, Mordovia RepublicRussia

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