Moscow University Biological Sciences Bulletin

, Volume 68, Issue 4, pp 153–157 | Cite as

Effects of chronic injections of clebopride in low doses on behavior reactions of white rats

  • A. V. Malyshev
  • A. M. Zakharov
  • K. Yu. Sarkisova
  • V. A. Dubynin


Effects of the selective D2 receptors antagonist clebopride on behavior of adult male rats was studied in such tests as sucrose consumption, open field, elevated plus maze, and complex maze with food reinforcement. The drug was injected in small doses (0.2 and 0.4 mg/kg) chronically within two weeks. It was shown that clebopride may have an influence on emotional and motivational state of experimental animals, on the one hand, causing depressive-like changes, and on the other hand, improving learning ability and exploratory reactions. A variety of consequences of D2 antagonist action is caused, apparently, by a competition of its post- and presynaptic effects.


dopamine brain system clebopride behavior depression learning 


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© Allerton Press, Inc. 2013

Authors and Affiliations

  • A. V. Malyshev
    • 1
  • A. M. Zakharov
    • 1
  • K. Yu. Sarkisova
    • 2
  • V. A. Dubynin
    • 1
  1. 1.Department of Human and Animal PhysiologyMoscow State UniversityMoscowRussia
  2. 2.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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