Moscow University Biological Sciences Bulletin

, Volume 65, Issue 4, pp 139–141 | Cite as

Comparison of protein phylogeny reconstruction methods using natural protein sequences

  • M. S. Krivozubov
  • S. A. Spirin


Comparison of several protein phylogeny reconstruction methods was realized on a set of natural protein sequences. The programs of the PHYLIP package and FastME, PhyML and TreeTop programs were tested. In contrast to several studied programs that used simulated sequences, our results demonstrate the superiority of distance methods over the maximum likelihood method.


phylogeny reconstruction algorithms protein sequences 


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© Allerton Press, Inc. 2010

Authors and Affiliations

  1. 1.Department of Bioengineering and Bioinformatics, Belozersky Institute of Physical and Chemical BiologyMoscow State UniversityMoscowRussia

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