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Synthesis and Biological Activity of Hybrid Systems of Magnetic Nanoparticles with Antibacterial Drugs

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Abstract—Nanoparticles of iron and magnetite, which have a high potential with respect to their magnetic properties, as well as antibacterial and antiviral activity, are included in hybrid nanosystems with antibacterial preparations of dioxidine and gentamicin sulfate by cryochemical synthesis. The composition, morphology, and antibacterial activity of the resulting systems were characterized by XRD, TEM, UV and IR spectroscopy, low-temperature nitrogen adsorption, and the disk diffusion test.

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ACKNOWLEDGMENTS

The authors thank Dr. Semenov, Senior Researcher at the Department of Biology, Moscow State University, for his help in determining the activity of the resulting antibacterial systems.

Funding

This work was supported by the Russian Science Foundation, project no. 16-13-10365.

Author information

Correspondence to T. I. Shabatina.

Ethics declarations

The authors declare that they have no conflict of interest.

Additional information

Translated by O. Zhukova

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Vernaya, O.I., Shumilkin, A.S., Shabatin, V.P. et al. Synthesis and Biological Activity of Hybrid Systems of Magnetic Nanoparticles with Antibacterial Drugs. Moscow Univ. Chem. Bull. 74, 322–325 (2019). https://doi.org/10.3103/S0027131419060154

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Keywords:

  • nanoparticles
  • iron
  • magnetite
  • dioxidine
  • gentamicin sulfate
  • antibacterial activity