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Moscow University Chemistry Bulletin

, Volume 74, Issue 3, pp 143–145 | Cite as

Quantification of Hexamethylenediamide Bis(N-Monosuccinyl-L-Seryl-L-Lysine) (GSB-106) in the Blood Plasma by HPLC–MS

  • O. G. GrybakinaEmail author
  • N. B. Lopatina
  • E. V. Blynskaya
  • P. O. Bochkov
  • R. V. Shevchenko
  • A. A. Litvin
  • G. B. Kolyvanov
  • V. P. Zherdev
  • S. E. Kondakov
Article
  • 3 Downloads

Abstract

The technique of the quantitative determination of GSB-106 in the blood plasma of rats is developed and validated. The analysis is performed by HPLC–MS. The method is linear in the range of 50 to 1000 ng/mL. The GSB-106 recovery from blood plasma was 82.15%. The lower limit of quantification was 50 ng/mL.

Keywords:

GSB-106 blood plasma HPLC–MS quantification 

Notes

FUNDING

This work was supported by the Ministry of Education and Science of the Russian Federation (government contract no. 14.N08.12.0086).

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Copyright information

© Allerton Press, Inc. 2019

Authors and Affiliations

  • O. G. Grybakina
    • 1
    Email author
  • N. B. Lopatina
    • 2
  • E. V. Blynskaya
    • 1
  • P. O. Bochkov
    • 1
  • R. V. Shevchenko
    • 1
  • A. A. Litvin
    • 1
  • G. B. Kolyvanov
    • 1
  • V. P. Zherdev
    • 1
  • S. E. Kondakov
    • 3
  1. 1.Zakusov Research Institute of PharmacologyMoscowRussia
  2. 2.Sechenov UniversityMoscowRussia
  3. 3.Department of Chemistry, Moscow State UniversityMoscowRussia

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