Multifunctional Lipoamino Acid Derivatives with Potential Biological Activity
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This work aims to develop a number of multifunctional derivatives of lipoamino acids, which potentially have different biological activities. To achieve this aim, the hydrophilic-lipophilic balance for a number of cationic amphiphile structures based on L-glutamic acid and short diamines is theoretically calculated. The developed schemes and performed synthesis allowed us to produce preparative sample quantities for further physicochemical and biological tests. The performed calculations, measurements, and experiments on the liposomal dispersions of the synthesized compounds demonstrate the possibility of designing the same type of structures of an amphiphilic nature based on aliphatic amino acid derivatives and diamines, which can be used both in antibacterial therapy and as the delivery vehicles for genetic material.
Keywordslipoamino acids diamines aliphatic derivatives of L-glutamic acid cationic liposomes hydrophilic- lipophilic balance cationic amphiphiles
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