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Moscow University Chemistry Bulletin

, Volume 71, Issue 4, pp 258–262 | Cite as

The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties

  • M. A. Orlova
  • T. P. Trofimova
  • S. V. Nikulin
  • A. P. Orlov
Article

Abstract

The effect of NO-synthase (NOS) activator and inhibitors on leukemic cell lines HL-60, K-562, and MOLT-4 and bone marrow cells of untreated patients diagnosed with B-cell acute lymphoblastic leukemia compared with lymphocytes from healthy donors is examined. The obtained data on the relationships between the radioprotective, NOS inhibitory, and cytotoxic properties of a number of thiazine, thiazoline, and thiourea derivatives indicates their potential for use as agents for complex radio- and chemotherapy.

Keywords

acute leukemia thiazine thiazoline thiourea derivatives NO-synthase inhibitors radioprotectors 

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Copyright information

© Allerton Press, Inc. 2016

Authors and Affiliations

  • M. A. Orlova
    • 1
    • 2
  • T. P. Trofimova
    • 1
    • 2
  • S. V. Nikulin
    • 2
    • 3
  • A. P. Orlov
    • 1
    • 4
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia
  2. 2.Rogachev Federal Scientific Clinical Centre of Pediatric HematologyOncology and ImmunologyMoscowRussia
  3. 3.Moscow Institute of Physics and TechnologyMoscowRussia
  4. 4.Scientific Centre for Expertise of Medical ProductsRussian Ministry of HealthMoscowRussia

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