Moscow University Chemistry Bulletin

, Volume 71, Issue 4, pp 258–262 | Cite as

The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties

  • M. A. Orlova
  • T. P. Trofimova
  • S. V. Nikulin
  • A. P. Orlov


The effect of NO-synthase (NOS) activator and inhibitors on leukemic cell lines HL-60, K-562, and MOLT-4 and bone marrow cells of untreated patients diagnosed with B-cell acute lymphoblastic leukemia compared with lymphocytes from healthy donors is examined. The obtained data on the relationships between the radioprotective, NOS inhibitory, and cytotoxic properties of a number of thiazine, thiazoline, and thiourea derivatives indicates their potential for use as agents for complex radio- and chemotherapy.


acute leukemia thiazine thiazoline thiourea derivatives NO-synthase inhibitors radioprotectors 


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  1. 1.
    Lyu, B.N., Usp. Sovrem. Biol., 2003, vol. 123, no. 2, p. 147.Google Scholar
  2. 2.
    Lara-Padilla, E. and Caceres-Cortes, J.R., Curr. Stem Cell Res. Ther., 2012, vol. 7, no. 1, p. 26.CrossRefGoogle Scholar
  3. 3.
    Titova, I.V., Sergeev, V.G., Yarilin, A.A., and Aktaev, I.G., Bull. Exp. Biol. Med., 2002, vol. 134, p. 407.CrossRefGoogle Scholar
  4. 4.
    Wallerath, T., Gath, I., and Aulizky, W.E., Thromb. Haemost., 1997, vol. 77, p. 163.Google Scholar
  5. 5.
    Chi, C., Ozawa, T., and Anzai, K., Biol. Pharm. Bull., 2006, vol. 29, no. 2, p. 348.CrossRefGoogle Scholar
  6. 6.
    Brandao, M.M., Soares, E., Salles, T., and Saad, S., Acta Haematol., 2000, vol. 106, p. 95.CrossRefGoogle Scholar
  7. 7.
    Cai, H., McNally, J.S., Weber, M., and Harrison, D.G., J. Mol. Cell Cardiol., 2004, vol. 37, p. 121.CrossRefGoogle Scholar
  8. 8.
    Mikhailenko, V.M., Demina, E.A., Musalov, I.I., and Gerashchenko, V.I., Exp. Oncol., 2013, vol. 35, no. 1, p. 58.Google Scholar
  9. 9.
    Konoplyanikov, A.G., Proskuryakov, S.Ya., Shtein, N.V., Kucherenko, N.G., Skvortsov, V.G., Ivannikov, A.I., Konoplyanikov, M.A., and Verkhovskii, Yu.G., Bull. Exp. Biol. Med., 1999, vol. 127, no. 6, p. 590.CrossRefGoogle Scholar
  10. 10.
    Proshin, A.N., Trofimova, T.P., and Bachurin, S.O., Russ. Chem. Bull., 2011, vol. 60, p. 2432.CrossRefGoogle Scholar
  11. 11.
    Schoberl, A. and Magosch, K.H., Liebigs Ann. Chem., 1970, vol. 742, p. 74.CrossRefGoogle Scholar
  12. 12.
    Trofimova, T.P., Zefirova, O.N., Mandrugin, A.A., Fedoseev, V.M., Peregud, D.I., Onufriev, M.N., Gulyaeva, N.V., and Proskuryakov, S.Ya., Moscow Univ. Chem. Bull., 2008, vol. 63, no. 5, p. 274.CrossRefGoogle Scholar
  13. 13.
    Trofimova, T.P., Pushin, A.N., Stash, A.I., Mandrugin, A.A., Fedoseev, V.M., and Proskuryakov, S.Ya., Chem. Heterocycl. Compd., 2007, vol. 43, no. 3, p. 370.CrossRefGoogle Scholar
  14. 14.
    Levtsova, A.A., Chupakhin, V.I., Proshin, A.N., Pushin, A.N., Trofimova, T.P., and Zefirova, O.N., Moscow Univ. Chem. Bull., 2007, vol. 62, no. 5, p. 243.CrossRefGoogle Scholar
  15. 15.
    Orlova, M.A., Osipova, E.Yu., and Roumiantsev, S.A., Br. J. Med. Med. Res., 2012, vol. 2, no. 1, p. 21.CrossRefGoogle Scholar
  16. 16.
    Veerman, A.J. and Pieters, R., Br. J. Haematol., 1990, vol. 74, p. 381.CrossRefGoogle Scholar
  17. 17.
    Stone, J.R., Sands, R.H., Dunham, W.R., and Marletta, M.A., Biochem. Biophys. Res. Commun., 1995, vol. 207, p. 575.CrossRefGoogle Scholar
  18. 18.
    Siripin, D., Fucharoen, S., and Tanyong, D.I., Asian Pac. J. Allergy Immunol., 2011, vol. 29, p. 102.Google Scholar
  19. 19.
    Rana, K., Reinhart-King, C.A., and King, M.R., Mol. Pharm., 2012, vol. 9, p. 2219.Google Scholar
  20. 20.
    Morgan, G., Med. Hypotheses, 2005, vol. 64, p. 661.CrossRefGoogle Scholar
  21. 21.
    Kuna, P. Chemická radioprotekce (Chemical Radioprotection), Praha: Avicenum, 1985.Google Scholar

Copyright information

© Allerton Press, Inc. 2016

Authors and Affiliations

  • M. A. Orlova
    • 1
    • 2
  • T. P. Trofimova
    • 1
    • 2
  • S. V. Nikulin
    • 2
    • 3
  • A. P. Orlov
    • 1
    • 4
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia
  2. 2.Rogachev Federal Scientific Clinical Centre of Pediatric HematologyOncology and ImmunologyMoscowRussia
  3. 3.Moscow Institute of Physics and TechnologyMoscowRussia
  4. 4.Scientific Centre for Expertise of Medical ProductsRussian Ministry of HealthMoscowRussia

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