Skip to main content
Log in

The medical perspective on burnout

  • Original Papers
  • Published:
International Journal of Occupational Medicine and Environmental Health

Abstract

Objective

The aim of this study was to review recent medical findings related to burnout, its diagnosis, treatment, characteristic pathophysiological features, and preventive measures.

Materials and Methods

A systematic review of the scientific literature in PubMed/Medline was performed. The most recent and important findings were reported.

Results

Burnout was found to be a risk factor for myocardial infarction and coronary heart disease. It was also related to reduced fibrinolytic capacity, decreased capacity to cope with stress and hypothalamic-pituitary-adrenal (HPA) axis hypoactivity. Severe burnout symptoms are associated with a lower level or smaller increase of the cortisol awakening response (CAR), higher dehydroepiandrosterone-sulphate (DHEAS) levels, lower cortisol/DHEAS ratios and stronger suppression as measured by the dexamethasone suppression test (DST). More and more literature works suggest that the evaluation of the HPA axis should be brought to the attention of primary care physicians. There is no universal agreement on specific treatment and diagnostic measures to evaluate the wide range of HPA axis disorders. The cost-effective evaluation of adrenal hormones via saliva samples by a primary care physician may significantly alter the course of therapy in numerous chronic disease patients. Psychiatric disorders may have similar symptoms, but they have distinctive hormonal profiles. Having burnout recognized as a medical condition would help in differentiating burnout from similar clinical syndromes, such as depression or anxiety, and provide appropriate treatment to burnout patients. Proper treatment is essential for a fast and full recovery.

Conclusion

Chronic stress-related disorders often fall outside the category of a “true” disease and are often treated as depression or not treated at all. The evaluation of adrenal hormones via saliva samples helps to predict burnout. Burnout screening techniques, dietary and nutritional guidelines and lifestyle changes for supporting the HPA function need to be developed. The presented material includes hormonal, dietary, and pharmaceutical perspectives.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Appels A. Why do imminent victims of a cardiac event feel so tired? Int J Clin Pract 1997;51:447–450.

    PubMed  CAS  Google Scholar 

  2. Maslach C, Schaufeli WB, Leiter MP. Job burnout. Annu Rev Psychol 2001;52:397–422.

    Article  PubMed  CAS  Google Scholar 

  3. Hallman T, Thomsson H, Burell G, Lisspers J, Setterlind S. Stress, burnout and coping: differences between women with coronary heart disease and healthy matched women. J Health Psychol 2003;8(4):433–445.

    Article  PubMed  Google Scholar 

  4. Appels A, Mulder P. Fatigue and heart disease. The association between ‘vital exhaustion’ and past, present and future coronary heart disease. J Psychosom Res 1989;33:727–738.

    Article  PubMed  CAS  Google Scholar 

  5. Pedersen SS, Middel B. Increased vital exhaustion among type-D patients with ischemic heart disease. J Psychosom Res 2001;51(2):443–449.

    Article  PubMed  CAS  Google Scholar 

  6. Räikkönen K, Lassila R, Keltikangas-Järvinen L, Hautanen A. Association of chronic stress with plasminogen activator inhibitor-1 in healthy middle-aged men. Arterioscler Thromb Vasc Biol 1996;16(3):363–367.

    Article  PubMed  Google Scholar 

  7. Keltikangas-Järvinen L, Räikkönen K, Hautanen A, Adlercreutz H. Vital exhaustion, anger expression, and pituitary and adrenocortical hormones. Implications for the insulin resistance syndrome. Arterioscler Thromb Vasc Biol 1996;16(2):275–280.

    Article  PubMed  Google Scholar 

  8. Nicolson NA, van Diest R. Salivary cortisol patterns in vital exhaustion. J Psychosom Res 2000;49(5):335–342.

    Article  PubMed  CAS  Google Scholar 

  9. Sandstrom A, Rhodin IN, Lundberg M, Olsson T, Nyberg L. Impaired cognitive performance in patients with chronic burnout syndrome. Biol Psychol 2005;69:271–279.

    Article  PubMed  Google Scholar 

  10. Esterling BA, Kiecolt-Glaser JK, Bodnar JC, Glaser R. Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults. Health Psychol 1994;13:291–298.

    Article  PubMed  CAS  Google Scholar 

  11. Maslach C, Jackson SE, Leiter MP. Maslach Burnout Inventory. Palo Alto, CA: Consulting Psychologist Press; 1996.

    Google Scholar 

  12. Barbosa FT, Leao BA, Tavares GM, Santos JG. Burnout syndrome and weekly workload of on-call physicians: Cross-sectional study. Sao Paulo Med J 2012;130(5):282–288.

    Article  PubMed  Google Scholar 

  13. Farber BA. Burnout in psychotherapists: Incidence, types, and trends. Psychother Priv Pract 1990;8(1):35–44.

    Article  Google Scholar 

  14. Farber BA. Treatment strategies for different types of teacher burnout. J Clin Psychol 2000;56:675–689.

    Article  PubMed  CAS  Google Scholar 

  15. Montero-Marín J, García-Campayo J, Mosquera Mera D, López del Hoyo Y. A new definition of burnout syndrome based on Farber’s proposal. J Occup Med Toxicol 2009;4(31):1–17.

    Google Scholar 

  16. Montero-Marín J, García-Campayo J, Fajó-Pascual M, Carrasco JM, Gascón S, Gili M, et al. Sociodemographic and occupational risk factors associated with the development of different burnout types: The cross-sectional University of Zaragoza study. BMC Psychiatry 2011;11(49):1–13.

    Google Scholar 

  17. Trickett S. Withdrawal from benzodiazepines. J R Coll Gen Pract 1983;33:608.

    Google Scholar 

  18. Lader M, Morton S. Benzodiazepine problems. Br J Addict 1991;86:823–828.

    Article  PubMed  CAS  Google Scholar 

  19. Michelini S, Cassano GB, Frare F, Perugi G. Long-term use of benzodiazepines: Tolerance, dependence and clinical problems in anxiety and mood disorders. Pharmacopsychiatry 1996;29:127–134.

    Article  PubMed  CAS  Google Scholar 

  20. Opstad K. Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men. Eur J Endocrinol 1994;131:56–66.

    Article  PubMed  CAS  Google Scholar 

  21. Ekstedt M, Söderström M, Akerstedt T, Nilsson J, Søndergaard HP, Aleksander P. Disturbed sleep and fatigue in occupational burnout. Scand J Work Environ Health 2006;32(2):121–131.

    Article  PubMed  Google Scholar 

  22. Doghramji K. Approach to the patient with a sleep or wakefulness disorder. The Merck Manual Online. [cited 2013 June 20]. Available from http://www.merckmanuals.com/professional/neurologic_disorders/sleep_and_wakefulness_disorders/approach_to_the_patient_with_a_sleep_or_wakefulness_disorder.html

  23. Ahola K, Honkonen T, Virtanen M, Kivimäki M, Isometsä E, Aromaa A, et al. Interventions in relation to occupational burnout: The population-based health 2000 study. J Occup Environ Med 2007;49(9):943–952.

    Article  PubMed  Google Scholar 

  24. Juster RP, Sindi S, Marin MF, Perna A, Hashemi A, Pruessner JC, et al. A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology 2011;36(6):797–805.

    Article  PubMed  CAS  Google Scholar 

  25. Sonnenschein M, Mommersteeg PM, Houtveen JH, Sorbi MJ, Schaufeli WB, van Doornen LJ. Exhaustion and endocrine functioning in clinical burnout: An in-depth study using the experience sampling method. Biol Psychol 2007;75(2):176–184.

    Article  PubMed  Google Scholar 

  26. Pariante CM, Hye A, Williamson R, Makoff A, Lovestone S, Kerwin RW. The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology 2003;28:1553–1561. DOI: 10.1038/sj.npp.1300195.

    Article  PubMed  CAS  Google Scholar 

  27. Pariante CM, Kim RB, Makoff A, Kerwin RW. Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. Br J Pharmacol 2003;139:1111–1118.

    Article  PubMed  CAS  Google Scholar 

  28. Karssen AM, Meijer OC, van der Sandt I, Lucassen PJ, de Lange EC, de Boer AG, et al. Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 2001;142(2):686–694.

    Google Scholar 

  29. Hotze SF. Adrenal Fatigue & Cortisol [cited 2013 June 20]. Available from http://www.cushings-help.com/downloads/adrenal.pdf

  30. Schuder SE. Stress-Induced Hypocortisolemia Diagnosed as Psychiatric Disorders Responsive to Hydrocortisone Replacement. Ann N Y Acad Sci 2005;1057:466–478.

    Article  PubMed  CAS  Google Scholar 

  31. Sagud M, Pivac N, Mück-Seler D, Jakovljević M, Mihaljević-Peles A, Korsić M. Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients. Neuropsychobiology 2002;45:139–143.

    Article  PubMed  CAS  Google Scholar 

  32. Schluger JH, Ho A, Borg L, Porter M, Maniar S, Gunduz M, et al. Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: Implications for the treatment of alcoholism. Alcohol Clin Exp Res 1998;22(7):1430–1436.

    Article  PubMed  CAS  Google Scholar 

  33. Petrosino S, Di Marzo V. FAAH and MAGL inhibitors: Therapeutic opportunities from regulating endocannabinoid levels. Curr Opin Invest Drugs 2010;11(1):51–62.

    CAS  Google Scholar 

  34. Guilliams TG, Edwards L. Chronic stress and the HPA axis: Clinical assessment and therapeutic considerations. The review of natural & neutraceutical therapies for clinical practice. Standard 2010;9(2):1–12.

    Google Scholar 

  35. Hamazaki K, Itomura M, Huan M. Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: A randomized, placebo-controlled, double-blind trial. Nutrition 2005;21:705–710.

    Article  PubMed  CAS  Google Scholar 

  36. Delarue J, Matzinger O, Binnert C. Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab 2003;29:289–295.

    Article  PubMed  CAS  Google Scholar 

  37. Hamazaki T, Itomura M, Sawazaki S, Nagao Y. Antistress effects of DHA. Biofactors 2000;13:41–45.

    Article  PubMed  CAS  Google Scholar 

  38. Krähenbühl S, Hasler F, Frey BM, Frey FJ, Brenneisen R, Krapf R. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J Clin Endocrinol Metab 1994;78(3):581–585.

    Article  PubMed  Google Scholar 

  39. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol 2006;46(3):167–192.

    Article  PubMed  CAS  Google Scholar 

  40. Head KH, Kelly GS. Nutrients and botanicals for treatment of stress: Adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev 2009;14(2):114–140.

    PubMed  Google Scholar 

  41. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009;4(3):198–219.

    Article  PubMed  CAS  Google Scholar 

  42. Pruessner JC, Hellhammer DH, Kirschbaum C. Burnout, perceived stress, and cortisol responses to awakening. Psychosom Med 1999;61(2):197–204.

    PubMed  CAS  Google Scholar 

  43. Clarke DM, Kissane DW. Demoralization: Its phenomenology and importance. Aust N Z J Psychiatry 2002;36(6):733–742.

    Article  PubMed  Google Scholar 

  44. Gabel S. Demoralization in mental health organizations: Leadership and social support help. Psychiatr Q 2012;83(4):489–496.

    Article  PubMed  Google Scholar 

  45. West CP, Dyrbye LN, Satele DV, Sloan JA, Shanafelt TD. Concurrent validity of single-item measures of emotional exhaustion and depersonalization in burnout assessment. Gen Intern Med 2012;27(11):1445–1452.

    Article  Google Scholar 

  46. Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, Sondeijker FE, Ormel J, Verhulst FC. Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 2007;116(2):137–144.

    Article  PubMed  CAS  Google Scholar 

  47. Kanter ED, Wilkinson CW, Radant AD, Petrie EC, Dobie DJ, McFall ME, et al. Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Biol Psychiatry 2001;50(4):238–245.

    Article  PubMed  CAS  Google Scholar 

  48. Moch SL, Panz VR, Joffe BI, Havlik I, Moch JD. Longitudinal changes in pituitaryadrenal hormones in South African women with burnout. Endocrine 2003;21(3):267–272.

    Article  PubMed  CAS  Google Scholar 

  49. Kellner M, Yehuda R, Arlt J, Wiedemann K. Longitudinal course of salivary cortisol in post-traumatic stress disorder. Acta Psychiatr Scand 2002;105(2):153–155

    Article  PubMed  Google Scholar 

  50. Yehuda R, Brand SR, Golier JA, Yang RK. Clinical correlates of DHEA associated with post-traumatic stress disorder. Acta Psychiatr Scand 2006;114(3):187–193.

    Article  PubMed  CAS  Google Scholar 

  51. Tiller JW, Biddle N, Maguire KP, Davies BM. The dexamethasone suppression test and plasma dexamethasone in generalized anxiety disorder. Biol Psychiatry 1988;23(3):261–270.

    Article  PubMed  CAS  Google Scholar 

  52. Montero-Marín J. The ‘Burnout Clinical Subtype Questionnaire’ (BCSQ-36/BCSQ-12): A new definition of burnout through a differential characterization of the syndrome. Huesca: Ediciones GH; 2012. p. 106.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tamar Kakiashvili.

About this article

Cite this article

Kakiashvili, T., Leszek, J. & Rutkowski, K. The medical perspective on burnout. IJOMEH 26, 401–412 (2013). https://doi.org/10.2478/s13382-013-0093-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s13382-013-0093-3

Key words

Navigation