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PTEN: A molecular target for neurodegenerative disorders

  • Review Article
  • Published:
Translational Neuroscience

Abstract

PTEN (phosphatase and tensin homologue deleted in chromosome 10) was first identified as a candidate tumour suppressor gene located on chromosome 10q23. It is considered as one of the most frequently mutated genes in human malignancies. Emerging evidence shows that the biological function of PTEN extends beyond its tumour suppressor activity. In the central nervous system PTEN is a crucial regulator of neuronal development, neuronal survival, axonal regeneration and synaptic plasticity. Furthermore, PTEN has been linked to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. Recently increased attention has been focused on PTEN as a potential target for the treatment of brain injury and neurodegeneration. In this review we discuss the essential functions of PTEN in the central nervous system and its involvement in neurodegeneration.

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Authors and Affiliations

  1. Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK

    Azza Ismail, Ke Ning & Mimoun Azzouz

  2. Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

    Abdulmonem Al-Hayani

  3. Neurology Department, Royal Hallamshire Hospital, Sheffield Teaching Hospital Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK

    Basil Sharrack

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  1. Azza Ismail
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  2. Ke Ning
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  3. Abdulmonem Al-Hayani
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  4. Basil Sharrack
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  5. Mimoun Azzouz
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Correspondence to Mimoun Azzouz.

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Ismail, A., Ning, K., Al-Hayani, A. et al. PTEN: A molecular target for neurodegenerative disorders. Translat.Neurosci. 3, 132–142 (2012). https://doi.org/10.2478/s13380-012-0018-9

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  • DOI: https://doi.org/10.2478/s13380-012-0018-9

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