Abstract
Negative and positive symptoms are defining features of schizophrenia. This illness is commonly associated with a number of cognitive and affective deficits as well as with some more specific sleep abnormalities. It has been previously proposed that psychosis and positive symptoms in schizophrenia could be understood as disorders of internal brain dynamics. This proposed disordered network interplay might be particularly displayed during sleep when modulation by the senses is at the minimum. It is argued here that sleep abnormalities in schizophrenia inform our understanding of the pathomechanisms involved in psychosis. More specifically, sleep spindle initiation in NREM sleep and the preparation of sensory pathways for upcoming motor actions during wakefulness may share a common mechanism, and this shared mechanism is suggested to be impaired in schizophrenia.
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Vukadinovic, Z. Similarities between cortical “up” states during slow wave sleep and wakefulness: the implications for schizophrenia. Translat.Neurosci. 3, 51–55 (2012). https://doi.org/10.2478/s13380-012-0004-2
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DOI: https://doi.org/10.2478/s13380-012-0004-2