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Optoelectronic method for detection of cervical intraepithelial neoplasia and cervical cancer

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Opto-Electronics Review

Abstract

The optoelectronic method is one of the most promising concepts of biophysical program of the diagnostics of CIN and cervical cancer. Objectives of the work are evaluation of sensitivity and specificity of the optoelectronic method in the detection of CIN and cervical cancer. The paper shows correlation between the pNOR number and sensitivity/specificity of the optoelectronic method. The study included 293 patients with abnormal cervical cytology result and the following examinations: examination with the use of the optoelectronic method — Truscreen, colposcopic examination, and histopathologic biopsy.

Specificity of the optoelectronic method for LGSIL was estimated at 65.70%, for HGSIL and squamous cell carcinoma of cervix amounted to 90.38%. Specificity of the optoelectronic method used to confirm lack of cervical pathology was estimated at 78.89%.

The field under the ROC curve for the optoelectronic method was estimated at 0.88 (95% CI, 0.84–0.92) which shows high diagnostic value of the test in the detection of HGSIL and squamous cell carcinoma.

The optoelectronic method is characterised by high usefulness in the detection of CIN, present in the squamous epithelium and squamous cell carcinoma of cervix.

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References

  1. D. Parkin, P. Pisani, and J. Frelay, “Estimates of the world-wide frequency of 18 major cancers in 1985”, Int. J. Cancer 54, 594–606 (1993).

    Article  Google Scholar 

  2. Center of Oncology Maria Sklodowska-Curie Memorial Institute, Cancer Epidemiology and Prevention Division, National Cancer Registry. http://epid.coi.waw.pl/krn/.

  3. D. Parkin, “The global health burden of infection-associated cancers in the year 2002”, Int. J. Cancer, 118, 3030–3044 (2006).

    Article  Google Scholar 

  4. W. Kędzia, M. Schmidt, E. Poręba, A. Goździcka-Józefiak, H. Kędzia, and M. Spaczyński, “Diagnosis of papilloma viruses in cervical cancer in 414 women from Wielkopolska region by the immunohistochemical assessment” Ginekol. Pol. 76, 584–554 (2005).

    Google Scholar 

  5. J. Walboomers, M. Jacobs, M. Marcel, M. Manos, F. Bosch, J. Kummer, K. Shah, P. Snijders, J. Peto, C. Meijer, and N. Muñoz, “Human papillomavirus is a necessary cause of invasive cervical cancer worldwide”, J. Pathol. 189, 12–19 (1999).

    Article  Google Scholar 

  6. R. Richart, “Natural history of cervical intraepithelial neoplasia”, Clin. Obstet. Gynecol. 10, 748 (1968).

    Google Scholar 

  7. K. Canfell and C. Chow, “Real-time devices for the screening and diagnosis of cervical neoplasia”, Part 6B Cervical neoplasia: screening, The Cervix, 2nd Edition, 2006.

  8. S. Abdul, B. Brown, P. Milnes, and J. Tidy, “The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia”, Int. J. Gynecol. Cancer 16, 1823–1832 (2006).

    Article  Google Scholar 

  9. R. Stoy, K. Foster, and H. Schwan, “Dielectric properties of mammalian tissues from 0.1 to 100 MHz: a summary of recent data”, Phys. Med. Biol. 27, 501–513 (1982).

    Article  Google Scholar 

  10. D. Jones, R. Smallwood, D. Hose, B. Brown, and D. Walker D, “Modelling of epithelial tissue impedance measured using three different designs of probe”, Physiol. Meas. 24, 605–623 (2003).

    Article  Google Scholar 

  11. Singer, M. Coppleson, K. Canfell, V. Skladnev, G. Mackellar, N. Pisal, and A. Deery, “A real time optoelectronic device as an adjunct to the Pap smear for cervical screening: a multicenter evaluation”, Int. J. Gynecol. Cancer 13, 804–811 (2003).

    Article  Google Scholar 

  12. M. Coppleson, B. Reid, V. Skladnev, and J. Dalrymple, “An electronic approach to the detection of pre-cancer and cancer of the uterine cervix: a preliminary evaluation of Polarprobe”, Int. J. Gynecol. Cancer 4, 79–83 (1994).

    Article  Google Scholar 

  13. S. Quek, T. Mould, K. Canfell, A. Singer, V. Skladnev, and M. Coppleson, “The polarprobe-emerging technology for cervical cancer screening”, Ann. Acad. Med. 27, 717–721 (1998).

    Google Scholar 

  14. M. Coppleson, B. Reid, V. Skladnev, and J. Dalrymple, “An electronic approach to the detection of pre-cancer and cancer of the uterine cervix: a preliminary evaluation of Polarprobe”, Int. J. Gynecol. Cancer 4, 79–83 (1994).

    Article  Google Scholar 

  15. A. Singer, M. Coppleson, K. Canfell, V. Skladnev, G. Mackellar, N. Pisal, and A. Deery, “A real time optoelectronic device as an adjunct to the Pap smear for cervical screening: a multicenter evaluation”, Int. J. Gynecol. Cancer 13, 804–811 (2003).

    Article  Google Scholar 

  16. D. Pruski, W. Kędzia, M. Przybylski, A. Józefiak, H. Kędzia, and M. Spaczyński, “Assessment of real optoelectronic method in the detection of cervical intraepithelial neoplasia”, Ginekol. Pol. 79, 342–346 (2008).

    Google Scholar 

  17. X. He, X. Luo, L. Mao, G. Chen, Y. Li, and J. Zhang, “An optoelectronic cervical cancer screening system for screening cervical cancer: comparison with cervical cytology”, Nan Fang Yi Ke Da Xue Xue Bao. 30, 2304–2306 (2010).

    Google Scholar 

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Authors and Affiliations

  1. Department of Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, 10 Fredry Str., 61-701, Poznań, Poland

    D. Pruski, M. Przybylski, W. Kędzia & M. Spaczyński

  2. Laboratory of Pathophysiology of Uterine Cervix in Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences, 10 Fredry Str., 61-701, Poznań, Poland

    D. Pruski, W. Kędzia & J. Jagielska-Pruska

  3. Pathomorphology Department in Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences, 10 Fredry Str., 61-701, Poznań, Poland

    H. Kędzia

Authors
  1. D. Pruski
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  2. M. Przybylski
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  3. W. Kędzia
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  4. H. Kędzia
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  5. J. Jagielska-Pruska
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  6. M. Spaczyński
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Correspondence to D. Pruski.

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Pruski, D., Przybylski, M., Kędzia, W. et al. Optoelectronic method for detection of cervical intraepithelial neoplasia and cervical cancer. Opto-Electron. Rev. 19, 478–485 (2011). https://doi.org/10.2478/s11772-011-0040-4

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  • DOI: https://doi.org/10.2478/s11772-011-0040-4

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