Abstract
Type II diabetes is a metabolic disorder characterized by hyperglycemia arising from defective insulin signaling. Several synthetic drugs are being used for diabetes treatment, but they have adverse effects. So as an alternative approach, compounds from plants with lesser/no side effects and comparatively cheaper are gaining momentum. Terpenes comprise a class of diversified phytochemicals, which have beneficial effects and important functions in plants. They have shown a series of biological properties that healthpromoting conduct in humans. Besides, a lot of terpenes have also been reported to be much less toxic as compared to synthetic compounds. Diabetic people could be benefited from terpenes obtained either from the diet or from plant-derived herbal medicines. Due to the natural origin of terpenes, they are supposed to be a safe and promising agent in eliminating the causes and effects of diabetes. This paper reviews the research reports of terpenes as their antidiabetic potential, mechanistic action, preclinical profile, shortcomings, and prospect in the effective management of diabetes.
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Abbreviations
- ACC:
-
Acetyl-CoA carboxylase
- ACE:
-
Angiotensin converting enzyme
- AGEs:
-
Advanced glycation end products
- AMPK:
-
AMP activated protein kinase
- AR:
-
Aldose reductase
- DAA:
-
Dehyroabietic acid
- DM:
-
Diabetes mellitus
- DPP IV:
-
Dipeptidyl peptidase IV
- DPPH:
-
2,2-diphenyl-1-picryhydrazyl
- ER:
-
Endoplasmic reticulum
- GADA:
-
Glutamic Acid Decarboxylose
- GLP:
-
Glucagon like peptide
- GSP:
-
Glycosylated serum protein
- HbA1c:
-
Haemoglobin A1c
- IA2A:
-
Insulinoma associated autoantigen 2
- IDDM:
-
Insulindependent diabetes mellitus
- IR:
-
Insulin receptor
- IRE1:
-
Inositol requiring enzyme 1
- IRS:
-
Insulin receptor substrate
- LC-MS:
-
liquid chromatography-mass spectrometry
- MAPK:
-
Mitogen-activated protein kinase
- MDA:
-
Malondialdehyde
- NF-kB:
-
Nuclear factor kappa-B
- NIDDM:
-
Noninsulindependent diabetes mellitus
- NLC:
-
Nano-structured lipid carriers
- NLRP3:
-
Nod like receptor family pyrin domain containing 3
- Nrf2:
-
Nuclear factor erythroid 2-related factor
- OGTT:
-
Oral glucose tolerance test
- PL:
-
Pancreatic lipase
- PPAR:
-
Peroxisome proliferator activator receptor
- PTP:
-
Protein tyrosine phosphatase
- ROS:
-
Reactive oxygen species
- SIRT1:
-
Silent mating type information regulation 2 homolog 1 overexpression
- SLN:
-
Solid lipid nanoparticles
- SOD:
-
Superoxide dismutase
- STZ :
-
Streptozotocin
- STZ-NA:
-
Streptozotocin-Nicotinamide
- TG :
-
Triglyceride
- TNF α:
-
Tumor necrosis factor-α
- TTA:
-
Total triterpene acid
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The authors are thankful to the GGU, Bilaspur (India), and NIT, Raipur (India) for support and facility. Financial assistance to SKP as SRF for Ph.D. from University Grants Commission (UGC), New Delhi, India is gratefully acknowledged.
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Panigrahy, S.K., Bhatt, R. & Kumar, A. Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics. Biologia 76, 241–254 (2021). https://doi.org/10.2478/s11756-020-00575-y
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DOI: https://doi.org/10.2478/s11756-020-00575-y