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Predictive value of plasma lipid levels for coronary artery disease (CAD)

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Coronary artery disease (CAD) is a major cause of mortality and morbidity all over the world including Pakistan. CAD events are caused by the interplay of genetic and environmental factors, the effects of which are mainly mediated through cardiovascular risk factors. The major risk factors for CAD include hypertension, dyslipidemia, family history of premature atheroscleclerotic disease, obesity and sedentary lifestyle. However, it is clear from the existing literature that dyslipidemia plays a central role. This study was designed to examine the plasma lipid profile in coronary artery disease patients of both sexes receiving clinical care at various government hospitals in Lahore. Blood samples were collected from a total of 500 CAD patients and 250 healthy (control) subjects and subsequently analyzed for total cholesterol (TC), triglyceride (TG) and very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein cholesterol (HDL) levels. These measurements showed that TC, LDL, TG and VLDL levels were significantly elevated, whereas HDL levels were significantly reduced in CAD patients as compared to ethnically matched controls (p < 0.0001). However, lipid levels did not differ significantly between the male and female patients. Furthermore, the lipid profile parameters were strongly associated with CAD status and association of LDL/HDL remained significant even after making an adjustment for confounders. In addition, patients with comorbidities exhibited severe lipid abnormalities. In conclusion, this study revealed elevated plasma TG, TC, VLDL and LDL levels and attenuated plasma HDL levels in the Pakistani patients with coronary artery disease. Also, plasma lipid levels have the potential to serve as biomarkers for CAD in Pakistani population.

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Coronary artery disease


Total Cholesterol




High density lipoprotein


low density lipoprotein


Very Low density


Cardiovascular diseases




Lipoprotein lipase


Lecithin cholesterol acyltranferase


Cholesterol ester transfer protein


Fasting blood glucose


Joint National Committee for Hypertension


Statistical Package for Social Sciences


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Dr. Salman Azhar, Associate Director for Research, Geriatric Research, Education and Clinical Center (GRECC), Adjunct Professor, Department of Medicine/Division of Endocrinology, Gerontology and Metabolism, School of Medicine, Stanford University is acknowledged for the critical revision of the paper for language, grammar and punctuation.

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Shahid, S.U., Shabana & Rehman, A. Predictive value of plasma lipid levels for coronary artery disease (CAD). Biologia (2020).

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  • Plasma lipoproteins,heart disease
  • Lipid biomarkers
  • Dyslipidemia