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Proton magnetic resonance spectroscopy in patients with solitary and sporadic temporal lobe epileptic seizures

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Abstract

Proton magnetic resonance spectroscopy (1H MRS) is an optional diagnostic method for potential epilepsy surgery candidates. The aim of this study was to determine the credibility of 1H MRS examination in a group of patients suffering from solitary and sporadic epileptic seizures generated in temporal lobe. We recorded a 100% sensitivity of 1H MRS in a group of ten patients in terms of detection of a pathological process in the temporal lobe. 1H MRS also enabled determination of lateralization of the pathological process in three patients with bilateral epileptiform abnormalities on electroencephalography. Based on these results we suggest new perspectives on 1H MRS as a part of standard diagnostic algorithm for solitary and sporadic temporal lobe epileptic seizures, particularly in cases with normal electroencephalography and magnetic resonance imaging findings.

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Abbreviations

Cho:

choline

Cr:

creatine

CSI:

chemical shift imaging

CT:

computed tomography

EEG:

electroencephalography

1H MRS:

proton magnetic resonance spectroscopy

MRI:

magnetic resonance imaging

LTM:

long-term monitoring

NAA:

N-acetylaspartate

SVS:

single voxel spectroscopy

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Authors and Affiliations

  1. 1st Department of Neurology, Faculty of Medicine, Comenius University, Mickiewiczova 13, SK-81369, Bratislava, Slovakia

    Branislav Kollár, Jana Borovská, Pavel Šiarnik, Lucia Krížová, Zuzana Čarnická, Stanislav Šutovský & Katarína Klobučníková

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  1. Branislav Kollár
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  2. Jana Borovská
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  3. Pavel Šiarnik
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  4. Lucia Krížová
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  5. Zuzana Čarnická
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  6. Stanislav Šutovský
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  7. Katarína Klobučníková
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Correspondence to Branislav Kollár.

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Kollár, B., Borovská, J., Šiarnik, P. et al. Proton magnetic resonance spectroscopy in patients with solitary and sporadic temporal lobe epileptic seizures. Biologia 67, 1245–1250 (2012). https://doi.org/10.2478/s11756-012-0119-5

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  • DOI: https://doi.org/10.2478/s11756-012-0119-5

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