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Chlamydia and mycoplasma infections during pregnancy and their relationships to orofacial cleft

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Abstract

Serum antibodies to Mycoplasma pneumoniae and Chlamydia trachomatis have been studied in a group of newborns with orofacial cleft (OC) and their mothers (n = 59) as compared to a control group of healthy newborns and their mothers (n = 40) assayed by ELISA and Western blot analysis. In the first group, IgG antibodies to M. pneumoniae were found by ELISA in 12 newborns with OC and 22 mothers, while IgA antibodies were detected only in 5 and 11 cases, respectively. IgM antibodies indicating an acute infection were found in 2 mothers only. IgG antibodies to C. trachomatis were found in 2 newborns with OC and 4 mothers. In the control group, IgG antibodies to M. pneumoniae were found in 3 newborns and 7 mothers. IgG antibodies to C trachomatis were observed in 1 newborn and 1 mother, while IgM antibodies to C trachomatis were present in 1 mother only. Immunoblot analysis revealed in newborns with OC and their mothers C. trachomatis-specific bands associated with MOMP 1, 29 kDa, 45 kDa, and heat shock proteins (HSP) 60 and 70. Based on these results we suggest that the risk associated with the exposure to M. pneumoniae and/or C. trachomatis is so far unknown and further study is needed for its elucidation.

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Authors and Affiliations

  1. Department of Plastic Surgery, Faculty of Medicine, Comenius University, Hospital Ružinov, Ružinovská 6, SK-82606, Bratislava, Slovakia

    Agáta Molnárová & Jozef Fedeleš

  2. Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia

    Elena Kováčová & Silvia Cvachová

  3. Department of Microbiology, Slovak Medical University, Bratislava, Slovakia

    Juraj Majtán

  4. Department of Gynecology, Faculty of Medicine, Comenius University, Hospital Ružinov, Bratislava, Slovakia

    Eva Bieliková

  5. Institute of Medical Biology and Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia

    Ján Vojtaššák & Vanda Repiská

Authors
  1. Agáta Molnárová
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  2. Elena Kováčová
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  3. Juraj Majtán
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  4. Jozef Fedeleš
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  5. Eva Bieliková
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  6. Silvia Cvachová
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  7. Ján Vojtaššák
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Correspondence to Agáta Molnárová.

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Molnárová, A., Kováčová, E., Majtán, J. et al. Chlamydia and mycoplasma infections during pregnancy and their relationships to orofacial cleft. Biologia 61, 719–723 (2006). https://doi.org/10.2478/s11756-006-0147-0

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  • DOI: https://doi.org/10.2478/s11756-006-0147-0

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