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Properties of poly(lactic acid-co-glycolic acid) film modified by blending with polyurethane

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Abstract

A number of poly(lactic acid-co-glycolic acid)/polyurethane (PLGA/PU) blend films with various PU mole contents were prepared by casting the polymer blend solution in chloroform. The surface morphologies of the PLGA/PU blend films were studied by scanning electron microscopy (SEM). The thermal, mechanical and chemical properties of the PLGA/PU blend films were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), tensile tests and surface contact angle tests. The results revealed that the introduction of PU could markedly modify the properties of PLGA films.

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References

  • Anderson, J. M., & Miller, K. M. (1984). Biomaterial biocompatibility and the macrophage. Biomaterials, 5, 5–10. DOI: 10.1016/0142-9612(84)90060-7.

    Article  CAS  Google Scholar 

  • Angelova, N., & Hunkeler, D. (1999). Rationalizing the design of polymeric biomaterials. Trends in Biotechnology, 17, 409–421. DOI: 10.1016/s0167-7799(99)01356-6.

    Article  CAS  Google Scholar 

  • Bai, L. Q., Zhu, L. J., Min, S. J., Liu, L., Cai, Y. R., & Yao, J. M. (2008). Surface modification and properties of Bombyx mori silk fibroin films by antimicrobial peptide. Applied Surface Science, 254, 2988–2995. DOI: 10.1016/j.apsusc.2007.10.049.

    Article  CAS  Google Scholar 

  • Bittner, B., Witt, C., Mäder, K., & Kissel, T. (1999). Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release. Journal of Controlled Release, 60, 297–309. DOI: 10.1016/s0168-3659(99)00085-1.

    Article  CAS  Google Scholar 

  • Blanco-Príeto, M. J., Besseghir, K., Zerbe, O., Andris, D., Orsolini, P., Heimgartner, F., Merkle, H. P., & Gander, B. (2000). In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres. Journal of Controlled Release, 67, 19–28. DOI: 10.1016/s0168-3659(99)00289-8.

    Article  Google Scholar 

  • Cleland, J. L., Johnson, O. L., Putney, S., & Jones, A. J. S. (1997). Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development. Advanced Drug Delivery Reviews, 28, 71–84. DOI: 10.1016/s0169-409x(97)00051-3.

    Article  CAS  Google Scholar 

  • Elbert, D. L., & Hubbell, J. A. (1998). Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers. Chemistry and Biology, 5, 177–183. DOI: 10.1016/s1074-5521(98)90062-x.

    Article  CAS  Google Scholar 

  • Ganji, F., & Abdekhodaie, M. J. (2010). Chitosan-g-PLGA copolymer as a thermosensitive membrane. Carbohydrate Polymers, 80, 740–746. DOI: 10.1016/j.carbpol.2009.12.021.

    Article  CAS  Google Scholar 

  • Göpferich, A., Peter, S. J., Lucke, A., Lu, L., & Mikos, A. G. (1999). Modulation of marrow stromal cell function using poly(d,l-lactic acid)-block-poly(ethylene glycol)-monomethyl ether surfaces. Journal of Biomedical Materials Research Part A, 46, 390–398. DOI: 10.1002/(SICI)1097-4636(19990905)46:3〈390::AID-JBM12〉3.0.CO;2-N.

    Article  Google Scholar 

  • Harjunalanen, T., & Lahtinen, M. (2003). The effects of altered reaction conditions on the properties of anionic poly(urethane-urea) dispersions and films cast from the dispersions. European Polymer Journal, 39, 817–824. DOI: 10.1016/s0014-3057(02)00279-3.

    Article  CAS  Google Scholar 

  • Holzer, M., Vogel, V., Mäntele, W., Schwartz, D., Haase, W., & Langer, K. (2009). Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage. European Journal of Pharmaceutics and Biopharmaceutics, 72, 428–437. DOI: 10.1016/j.ejpb.2009.02.002.

    Article  CAS  Google Scholar 

  • Houchin, M. L., Neuenswander, S. A., & Topp, E. M. (2007). Effect of excipients on PLGA film degradation and the stability of an incorporated peptide. Journal of Controlled Release, 117, 413–420. DOI: 10.1016/j.jconrel.2006.11.023.

    Article  CAS  Google Scholar 

  • Ignatius, A. A., & Claes, L. E. (1996). In vitro biocompatibility of bioresorbable polymers: poly(l, dl-lactide) and poly(l-lactide-co-glycolide). Biomaterials, 17, 831–839. DOI: 10.1016/0142-9612(96)81421-9.

    Article  CAS  Google Scholar 

  • Jain, R. A. (2000). The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials, 21, 2475–2490. DOI: 10.1016/s0142-9612(00)00115-0.

    Article  CAS  Google Scholar 

  • Jeong, J. H., Lim, D. W., Han, D. K., & Park, T. G. (2000). Synthesis, characterization and protein adsorption behaviors of PLGA/PEG di-block co-polymer blend films. Colloids and Surfaces B: Biointerfaces, 18, 371–379. DOI: 10.1016/s0927-7765(99)00162-9.

    Article  CAS  Google Scholar 

  • Kondo, T., Sawatari, C., Manley, R. S. J., & Gray, D. G. (1994). Characterization of hydrogen bonding in cellulose-synthetic polymer blend systems with regioselectively sub stituted methylcellulose. Macromolecules, 27, 210–215. DOI: 10.1021/ma00079a031.

    Article  CAS  Google Scholar 

  • Langer, R. (1995). 1994 Whitaker lecture: Polymers for drug delivery and tissue engineering. Annals of Biomedical Engineering, 23, 101–111. DOI: 10.1007/bf02368317.

    Article  CAS  Google Scholar 

  • Lio, K., Minoura, N., & Nagura, M. (1995). Swelling characteristics of a blend hydrogel made of poly(allylbiguanido-co-allylamine) and poly(vinyl alcohol). Polymer, 36, 2579–2583. DOI: 10.1016/0032-3861(95)91204-k.

    Article  Google Scholar 

  • Loo, S. C. J., Ooi, C. P., & Boey, Y. C. F. (2004). Radiation effects on poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA). Polymer Degradation and Stability, 83, 259–265. DOI: 10.1016/s0141-3910(03)00271-4.

    Article  CAS  Google Scholar 

  • Loo, S. C. J., Ooi, C. P., Wee, S. H. E., & Boey, Y. C. F. (2005). Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA). Biomaterials, 26, 2827–2833. DOI: 10.1016/j.biomaterials.2004.08.031.

    Article  CAS  Google Scholar 

  • Murakami, H., Kobayashi, M., Takeuchi, H., & Kawashima, Y. (2000). Utilization of poly(dl-lactide-co-glycolide) nanoparticles for preparation of mini-depot tablets by direct compression. Journal of Controlled Release, 67, 29–36. DOI: 10.1016/s0168-3659(99)00288-6.

    Article  CAS  Google Scholar 

  • Nishio, Y., & Manley, R. S. J. (1988). Cellulose-poly(vinyl alcohol) blends prepared from solutions in N,N-dimethylacetamide-lithium chloride. Macromolecules, 21, 1270–1277. DOI: 10.1021/ma00183a016.

    Article  Google Scholar 

  • Park, J. S., Park, J. W., & Ruckenstein, E. (2001). Thermal and dynamic mechanical analysis of PVA/MC blend hydogels. Polymer, 42, 4271–4280. DOI: 10.1016/s0032-3861(00)00768-0.

    Article  CAS  Google Scholar 

  • Park, B. J., Seo, H. J., Kim, J., Kim, H. L., Kim, J. K., Choi, J. B., Han, I., Hyun, S. O., Chung, K. H., & Park, J. C. (2010). Cellular responses of vascular endothelial cells on surface modified polyurethane films grafted electospun PLGA fiber with microwave-induced plasma at atmospheric pressure. Surface & Coatings Technology, 205, s222–s226. DOI: 10.1016/j.surfcoat.2010.07.087.

    Article  CAS  Google Scholar 

  • Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000). Physicochemical foundations and structural design of hydrogels in medicine and biology. Annual Review of Biomedical Engineering, 2, 9–29. DOI: 10.1146/annurev.bioeng.2.1.9.

    Article  CAS  Google Scholar 

  • Rowlands, A. S., Lim, S. A., Martin, D., & Cooper-White, J. J. (2007). Polyurethane/poly(lactic-co-glycolic) acid composite scaffolds fabricated by thermally induced phase separation. Biomaterials, 28, 2109–2121. DOI: 10.1016/j.biomaterials.2006.12.032.

    Article  CAS  Google Scholar 

  • Sawatari, C., & Kondo, T. (1999). Interchain hydrogen bonds in blend films of poly(vinyl alcohol) and its derivatives with poly(ethylene oxide). Macromolecules, 32, 1949–1955. DOI: 10.1021/ma980900o.

    Article  CAS  Google Scholar 

  • Schliecker, G., Schmidt, C., Fuchs, S., Wombacher, R., & Kissel, T. (2003). Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. International Journal of Pharmaceutics, 266, 39–49. DOI: 10.1016/s0378-5173(03)00379-x.

    Article  CAS  Google Scholar 

  • Steele, T. W. J., Huang, C. L., Widjaja, E., Boey, F. Y. C., Loo, J. S. C., & Venkatraman, S. S. (2011). The effect of polyethylene glycol structure on paclitaxel drug release and mechanical properties of PLGA thin films. Acta Biomaterialia, 7, 1973–1983. DOI: 10.1016/j.actbio.2011.02.002.

    Article  CAS  Google Scholar 

  • Stolnik, S., Dunn, S. E., Garnett, M. C., Davies, M. C., Coombes, A. G. A., Taylor, D. C., Irving, M. P., Purkiss, S. C., Tadros, T. F., Davis, S. S., & Illum, L. (1994). Surface modification of poly (lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharmaceutical Research, 11, 1800–1808. DOI: 10.1023 /a:1018931820564.

    Article  CAS  Google Scholar 

  • Sung, C. S. P., Smith, T. W., & Sung, N. H. (1980). Properties of segmented polyether poly(urethaneureas) based of 2,4-toluene diisocyanate. 2. Infrared and mechanical studies. Macromolecules, 13, 117–121. DOI: 10.1021/ma60073a023.

    Article  CAS  Google Scholar 

  • Tanaka, H., Suzuki, Y., & Yoshino, F. (1999). Synthesis and coating application of waterborne fluoroacrylic-polyurethane composite dispersions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 153, 597–601. DOI: 10.1016/s0927-7757(98)00482-8.

    Article  CAS  Google Scholar 

  • Thanki, P. N., Dellacherie, E., & Six, J. L. (2006). Surface characteristics of PLA and PLGA films. Applied Surface Science, 253, 2758–2764. DOI: 10.1016/j.apsusc.2006.05.047.

    Article  Google Scholar 

  • Vey, E., Roger, C., Meehan, L., Booth, J., Claybourn, M., Miller, A. F., & Saiani, A. (2008). Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution. Polymer Degradation and Stability, 93, 1869–1876. DOI: 10.1016/j.polymdegradstab.2008.07.018.

    Article  CAS  Google Scholar 

  • Yoon, S. D., Park, M. H., & Byun, H. S. (2012). Mechanical and water barrier properties of starch/PVA composite films by adding nano-sized poly(methyl methacrylate-coacrylamide) particles. Carbohydrate Polymers, 87, 676–686. DOI: 10.1016/j.carbpol.2011.08.046.

    Article  CAS  Google Scholar 

  • Zhu, G. Q., Wang, F. G., Gao, Q. C., Li, G. C., & Wang, P. (2011). Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group. Chemical Papers, 65, 483–489. DOI: 10.2478/s11696-011-0032-3.

    Article  CAS  Google Scholar 

  • Zou, M. X., Wang, S. J., Zhang, Z. C., & Ge, X. W. (2005). Preparation and characterization of polysiloxane-poly(butyl acrylate-styrene) composite latices and their film properties. European Polymer Journal, 41, 2602–2613. DOI: 10.1016/j.eurpolymj.2005.05.038.

    Article  CAS  Google Scholar 

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Correspondence to Fa-Gang Wang.

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Zhu, GQ., Wang, FG., Tan, HS. et al. Properties of poly(lactic acid-co-glycolic acid) film modified by blending with polyurethane. Chem. Pap. 68, 246–252 (2014). https://doi.org/10.2478/s11696-013-0438-1

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