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Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins

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Abstract

This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals’ concentration over a range of 10−6-10−5 mol L−1. Cu2+ accentuates lipoperoxidation but, when rosmarinic acid was present, Cu2+ produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu2+ and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1.

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Authors and Affiliations

  1. National Institute of Research and Development for Biological Science, 296 Splaiul Independentei, 060031, Bucharest, Romania

    Andreia Tache, Gabriel-Lucian Radu & Simona-Carmen Litescu

  2. Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, 1-7 Polizu, 0101061, Bucharest, Romania

    Andreia Tache & Gabriel-Lucian Radu

Authors
  1. Andreia Tache
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  2. Gabriel-Lucian Radu
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  3. Simona-Carmen Litescu
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Correspondence to Gabriel-Lucian Radu.

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Tache, A., Radu, GL. & Litescu, SC. Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins. Chem. Pap. 66, 1166–1170 (2012). https://doi.org/10.2478/s11696-012-0233-4

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  • DOI: https://doi.org/10.2478/s11696-012-0233-4

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