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Ethylcellulose, polycaprolactone, and eudragit matrices for controlled release of piroxicam from tablets and microspheres

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Abstract

The present paper provides details of the preparation of polymeric tablets and microspheres based on piroxicam as a therapeutic active agent and the drug release study from these formulations. Tablets composed of ethylcellulose, Eudragit® or mixtures of Eudragit® and synthesised poly(oxepan-2-one) were prepared and tested. The effect of the matrix on the drug release at 37°C was studied. The drug-loaded microparticles were prepared using solvent evaporation microencapsulation. These systems were characterised by SEM and FTIR spectroscopy and the size and size distribution were also determined. The results demonstrated that the drug release could be modified by means of these formulations. Finally, piroxicam dissolution rate constants were calculated from Higuchi’s release model.

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Authors and Affiliations

  1. Laboratory of Macromolecular and Physical Organic Chemistry, Faculty of Sciences, Djillali Liabès University, 22000, Sidi Bel Abbès, Algeria

    Kheira Diaf, Zineb El Bahri, Nafa Chafi, Lahcen Belarbi & Abderrezzak Mesli

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  1. Kheira Diaf
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  2. Zineb El Bahri
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  3. Nafa Chafi
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  4. Lahcen Belarbi
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  5. Abderrezzak Mesli
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Correspondence to Nafa Chafi.

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Diaf, K., Bahri, Z.E., Chafi, N. et al. Ethylcellulose, polycaprolactone, and eudragit matrices for controlled release of piroxicam from tablets and microspheres. Chem. Pap. 66, 779–786 (2012). https://doi.org/10.2478/s11696-012-0191-x

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