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4β-Isocyanopodophyllotoxins: valuable precursors for the synthesis of new podophyllotoxin analogues

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Abstract

A new and efficient method for the synthesis of novel 4β-isocyanopodophyllotoxins as a valuable building block for the synthesis of versatile bioactive podophyllotoxin analogues under both classical and ultrasonic conditions was developed. In general, significant improvements in rates of reaction and yields of sonochemical reactions relative to the classical ones were observed.

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Authors and Affiliations

  1. School of Pharmacy, Lanzhou University, Lanzhou, 730000, China

    Ying-Qian Liu, Lin-Hai Li & Wen-Qun Li

  2. Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Danzhou, 571737, China

    Gang Feng

  3. Environmental and Municipal Engineering School, Lanzhou Jiaotong University, Lanzhou, 730000, China

    Liu Yang

Authors
  1. Ying-Qian Liu
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  2. Lin-Hai Li
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  3. Wen-Qun Li
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  4. Gang Feng
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  5. Liu Yang
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Correspondence to Ying-Qian Liu.

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Liu, YQ., Li, LH., Li, WQ. et al. 4β-Isocyanopodophyllotoxins: valuable precursors for the synthesis of new podophyllotoxin analogues. Chem. Pap. 65, 739–742 (2011). https://doi.org/10.2478/s11696-011-0062-x

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  • DOI: https://doi.org/10.2478/s11696-011-0062-x

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