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Synthesis and study of some new N-substituted imide derivatives as potential antibacterial agents

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Abstract

Dibenzobarrelene (I) was used as a starting compound for the synthesis of some new 3a,4,9,9a-tetrahydro-4,9-[1,2]benzeno-1H-benzo[f]isoindole-1,3(2H)-diones, N-substituted with: 4-toluenesulfonyloxy, III; butoxy, IV; 3-bromopropoxy, V; 3-(4-phenylpiperazin-1-yl)propoxy, VI; 3-chloro-3-oxopropyl, VIII; 3-(4-phenylpiperazin-1-yl)-3-oxopropyl, IXa; 3-(4-methylpiperazin-1-yl)-3-oxopropyl, IXb; 3-oxo-3-(piperidin-1-yl)propyl, X; 3-morpholino-3-oxopropyl, XI; 3-phenylamino-3-oxopropyl, XII; 2-acetylaminoethyl, XIV; 2-aminoethyl, XV, and 2-acetoxyethyl, XVI. Newly synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data. Selected products were tested for antimicrobial activity.

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  1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

    Abd El-Galil M. Khalil, Moged A. Berghot & Moustafa A. Gouda

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  1. Abd El-Galil M. Khalil
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  2. Moged A. Berghot
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  3. Moustafa A. Gouda
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Correspondence to Moustafa A. Gouda.

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Khalil, A.EG.M., Berghot, M.A. & Gouda, M.A. Synthesis and study of some new N-substituted imide derivatives as potential antibacterial agents. Chem. Pap. 64, 637–644 (2010). https://doi.org/10.2478/s11696-010-0049-z

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