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1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions

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Abstract

Efficient syntheses of 3,4-dihydropyrimidin-2-(1H)-ones and the corresponding thioxo derivatives using 1,3-dibromo-5,5-dimethylhydantoin (DBH) catalysis of a one-pot three-component Biginelli reaction of aldehydes, ethyl acetoacetate, and urea or thiourea under microwave irradiation are described. The advantages of this method are its short reaction times, high yields of the products, inexpensive and commercially available catalyst, and solvent-free conditions. Typical isolated yields exceed 70 % for arylaldehydes (9 examples) and aliphatic aldehydes (2 examples).

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  1. Department of Chemistry, Yazd University, 89195-741, Yazd, Iran

    Mohammad Abdollahi-Alibeik & Zahra Zaghaghi

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  1. Mohammad Abdollahi-Alibeik
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  2. Zahra Zaghaghi
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Correspondence to Mohammad Abdollahi-Alibeik.

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Abdollahi-Alibeik, M., Zaghaghi, Z. 1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions. Chem. Pap. 63, 97–101 (2009). https://doi.org/10.2478/s11696-008-0084-1

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