Abstract
Trisodium O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl) diphosphates were synthesized from sodium dimethylamido-O-(2-cyanoethyl) phosphate and O-alkyl-and O-aryl phosphoric acids. While in the previously described method, sodium hydroxide was used for the preparation of O-phenyl diphosphate, in our current work, we present an improved protocol, where sodium methoxide is used to increase the yields of O-alkyl and O-aryl diphosphates. The structures of final compounds were determined by 1H NMR, 31P NMR, and IR spectroscopy. The sodium O-alkyl- and O-aryl diphosphate salts prepared by this method may be used for the study of biological activity of diphosphate analogues.
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Gregáň, F., Melicherčík, M., Gregáň, J. et al. Preparation of trisodium O-monoalkyl and O-monoaryl diphosphates. Chem. Pap. 62, 223–226 (2008). https://doi.org/10.2478/s11696-008-0015-1
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DOI: https://doi.org/10.2478/s11696-008-0015-1