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Furan-containing thiacyanine analogs and their antimicrobial activity

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Abstract

Condensation of quaternary 2-methylbenzothiazolium bromides with 5-(dialkylamino)furan-2-carbaldehydes afforded a series of new thiacyanine analogs. The compounds exhibit significant activities against several bacterial, yeast, and mould strains. Derivatives with dipropylamino substituents showed higher inhibitory effects than those with cyclic secondary amino groups. Hence, the biological activity may have been influenced by the lipophilicity of the compounds. The effect on growth and on the plastid system of the unicellular flagellate Euglena gracilis was also studied.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Natural Sciences, St. Cyril and Methodius University, SK-917 01, Trnava, Slovakia

    I. Kortišová & J. Halgaš

  2. Institute of Subcellular Biology, Faculty of Natural Sciences, Comenius University, SK-842 15, Bratislava, Slovakia

    P. Foltínová

Authors
  1. I. Kortišová
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  2. P. Foltínová
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  3. J. Halgaš
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Kortišová, I., Foltínová, P. & Halgaš, J. Furan-containing thiacyanine analogs and their antimicrobial activity. Chem. Pap. 60, 52–55 (2006). https://doi.org/10.2478/s11696-006-0009-9

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  • DOI: https://doi.org/10.2478/s11696-006-0009-9

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