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Presence of Seropositive Patients to Trypanosoma cruzi in a Municipality of the Mixtec Sierra of the State of Puebla: A Preliminary Study

Acta Parasitologica volume 65, pages 19–26 (2020)Cite this article

Abstract

Purpose

The state of Puebla has the social marginalization and ecological conditions for the transmission of infectious agents to be effective. Until a few years ago, the state of Puebla was considered non-endemic to the presence of Trypanosoma cruzi as there are no official reports of chronic cases. The objective of this work was to carry out a preliminary study on the prevalence of anti-T. cruzi antibodies in rural areas of the Huatlatlauca municipality in the Mixtec sierra of the state of Puebla.

Methods

A total of 196 serum samples from 12 rural localities were tested by using four tests: two enzyme-linked immunosorbent assays, an xenodiagnoses and PCR assay.

Results

Overall, 28 (14.2%) of 196 samples were positive for T. cruzi by ≥ 2 tests (95% CI 6.6–20.8%). Our results suggested that the municipality of Huatlatlauca in the Mixteca Sierra of the state of Puebla is an area with endemic potential for the disease with a high prevalence rate in the adult population and with cases in newborns, these high transmission rates are probably associated with problems of congenital and vector transmission.

Conclusion

Additional studies should be conducted to generate adequate campaigns for the control of Chagas disease in this area.

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Acknowledgements

The authors would like to thank the vice-rectory of research and post-grade studies of the Meritorious Autonomous University of Puebla.

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Affiliations

  1. Laboratorio de Parásitos y Vectores, Facultad de Biología, Universidad Benemérita del Estado de Puebla, Puebla, Mexico

    L. Zumaquero-Ríos, J. Sarracent-Pérez, C. Sandoval-Ruiz & R. M. Aldana-Arnas

  2. LADISER Inmunología y Biología Molecular, Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico

    A. López-Monteon, J. Torres-Montero, D. Guzmán-Gómez & A. Ramos-Ligonio

Authors
  1. L. Zumaquero-Ríos
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  2. J. Sarracent-Pérez
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  3. C. Sandoval-Ruiz
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  4. R. M. Aldana-Arnas
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  5. A. López-Monteon
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  6. J. Torres-Montero
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  7. D. Guzmán-Gómez
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  8. A. Ramos-Ligonio
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Correspondence to A. Ramos-Ligonio.

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Zumaquero-Ríos, L., Sarracent-Pérez, J., Sandoval-Ruiz, C. et al. Presence of Seropositive Patients to Trypanosoma cruzi in a Municipality of the Mixtec Sierra of the State of Puebla: A Preliminary Study. Acta Parasit. 65, 19–26 (2020). https://doi.org/10.2478/s11686-019-00118-9

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Keywords

  • Seroprevalence
  • Trypanosoma cruzi
  • Antibodies
  • Chagas disease
  • Puebla state